Human Cob (I) yrinic acid a; c-diamide adenosyltransferase; mitochondrial (MMAB) ELISA kit; ATR; MGC20496; cblB; cob; ATP:cob (I) alamin adenosyltransferase; ATP:corrinoid adenosyltransferase; aquocob (I) alamin vitamin B12s adenosyltransferase; cob (I) alamin adenosyltransferase; cob (I) yrinic acid; methylmalonic aciduria (cobalamin deficiency) cblB type

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of MMAB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9333321 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MMAB. The ELISA analytical biochemical technique of the MBS9333321 kit is based on MMAB antibody-MMAB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MMAB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MMAB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MMAB (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

27,388 Da

methylmalonic aciduria (cobalamin deficiency) cblB type

cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; ATP:corrinoid adenosyltransferase; ATP:cob(I)alamin adenosyltransferase; methylmalonic aciduria type B protein; cilia and flagella associated protein 23; aquocob(I)alamin vitamin B12s adenosyltransferase

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial

MMAB_HUMAN

This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]

MMAB: Defects in MMAB are the cause of methylmalonic aciduria type cblB (MMAB); also known as methylmalonic aciduria type B or vitamin B12-responsive methylmalonicaciduria of cblB complementation type. MMAB is a disorder of methylmalonate and cobalamin metabolism due to defective synthesis of adenosylcobalamin. Inheritance is autosomal recessive. Belongs to the Cob(I)alamin adenosyltransferase family.

Protein type: Transferase; Motility/polarity/chemotaxis; EC 2.5.1.17; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: mitochondrial matrix

Molecular Function: cob(I)yrinic acid a,c-diamide adenosyltransferase activity; ATP binding

Biological Process: vitamin metabolic process; cobalamin biosynthetic process; cobalamin metabolic process; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria, Cblb Type

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