Tyrosine-protein phosphatase non-receptor type 14; Protein-tyrosine phosphatase pez; PTPN14; PEZ; PTPD2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This PTPN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 862-890 amino acids from the C-terminal region of human PTPN14.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PTPN14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an N-terminal
noncatalytic domain similar to that of band 4.1 superfamily
cytoskeleton-associated proteins, which suggested the membrane or
cytoskeleton localization of this protein. It appears to regulate
lymphatic development in mammals, and a loss of function mutation
has been found in a kindred with a lymphedema-choanal atresia.

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

PTPN14 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the PTPN14 antibody detected the PTPN14 protein (arrow).

135261

protein tyrosine phosphatase, non-receptor type 14

tyrosine-protein phosphatase non-receptor type 14

Tyrosine-protein phosphatase non-receptor type 14

PEZ; PTPD2??[Similar Products]

PTN14_HUMAN

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleus

Molecular Function: protein binding; transcription cofactor activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding

Biological Process: negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lymphangiogenesis; protein amino acid dephosphorylation; regulation of protein export from nucleus

Disease: Choanal Atresia And Lymphedema

Au, A.C., et al. Am. J. Hum. Genet. 87(3):436-444(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wyatt, L., et al. Cell Cycle 7(15):2290-2295(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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