Product Name
RAB27A, Polyclonal Antibody
Full Product Name
RAB27A Antibody
Product Gene Name
anti-RAB27A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-RAB27A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAB27A antibody
Rabbit polyclonal RAB27A (1) antibody was raised against a recombinate human RAB27A protein 1-215aa (BC132800).
Product Categories/Family for anti-RAB27A antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-RAB27A antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-RAB27A antibody
ELISA: 1:20,000-1:80,000
WB: 1:500-1:1,000
Testing Data of anti-RAB27A antibody
NCBI/Uniprot data below describe general gene information for RAB27A. It may not necessarily be applicable to this product.
NCBI Accession #
BC132800
[Other Products]
UniProt Secondary Accession #
O00195; Q6FI40; Q9UIR9; Q9Y5U3[Other Products]
UniProt Related Accession #
P51159[Other Products]
Molecular Weight
24,041 Da
NCBI Official Full Name
Homo sapiens RAB27A, member RAS oncogene family, mRNA
NCBI Official Synonym Full Names
RAB27A, member RAS oncogene family
NCBI Official Symbol
RAB27A??[Similar Products]
NCBI Official Synonym Symbols
GS2; RAM; RAB27; HsT18676
??[Similar Products]
NCBI Protein Information
ras-related protein Rab-27A
UniProt Protein Name
Ras-related protein Rab-27A
UniProt Synonym Protein Names
GTP-binding protein Ram
Protein Family
Ras-related protein
UniProt Gene Name
RAB27A??[Similar Products]
UniProt Synonym Gene Names
RAB27; Rab-27??[Similar Products]
NCBI Summary for RAB27A
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for RAB27A
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Product References and Citations for anti-RAB27A antibody
(1) Elstak, E.D., Neeft, M., Nehme, N.T. et al. The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane. Blood 118 (6), 1570-1578 (2011).
Research Articles on RAB27A
1. Here, we report on a new RAB27A genetic anomaly observed in seven Saudi Arabia families that had remained negative after extensive molecular genomic DNA testing. Linkage analysis and targeted sequencing of the RAB27A genomic region in several of these patients led to the identification of a common homozygous tandem duplication of 38 kb affecting exon 2-5 and resulting in a premature stop codon
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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