Product Name
protein tyrosine phosphatase, non-receptor type 14 (PTPN14), Polyclonal Antibody
Full Product Name
Rabbit anti-human protein tyrosine phosphatase, non-receptor type 14 polyclonal Antibody
Product Synonym Names
protein tyrosine phosphatase; non-receptor type 14; PTPN14; MGC126803; PEZ; PTP36
Product Gene Name
anti-PTPN14 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-66614 / sc-66615 / sc-66616 / sc-68384
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-PTPN14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PTPN14 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for PTPN14. It may not necessarily be applicable to this product.
NCBI Accession #
AAI04804.1
[Other Products]
UniProt Secondary Accession #
Q5VSI0[Other Products]
UniProt Related Accession #
Q15678[Other Products]
Molecular Weight
135,261 Da[Similar Products]
NCBI Official Full Name
Protein tyrosine phosphatase, non-receptor type 14
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 14
NCBI Official Symbol
PTPN14??[Similar Products]
NCBI Official Synonym Symbols
PEZ; PTP36
??[Similar Products]
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 14; protein-tyrosine phosphatase pez; cytoskeletal-associated protein tyrosine phosphatase
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 14
UniProt Synonym Protein Names
Protein-tyrosine phosphatase pez
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN14??[Similar Products]
UniProt Synonym Gene Names
PEZ; PTPD2??[Similar Products]
UniProt Entry Name
PTN14_HUMAN
NCBI Summary for PTPN14
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
UniProt Comments for PTPN14
PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleus
Molecular Function: protein binding; transcription cofactor activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding
Biological Process: negative regulation of cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lymphangiogenesis; protein amino acid dephosphorylation; regulation of protein export from nucleus
Disease: Choanal Atresia And Lymphedema
Research Articles on PTPN14
1. Data demonstrate that PTPN14 downregulation can phenocopy YAP activation in mammary epithelial cells and synergize with YAP to induce oncogenic transformation.
Precautions
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Disclaimer
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