Product Name
Matrilin-3 (MATN3), Recombinant Protein
Full Product Name
Recombinant Human Matrilin-3 (MATN3)
Product Gene Name
MATN3 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
29-486aa, Full Length of Mature Protein
Sequence
DPVARPGFRR LETRGPGGSP GRRPSPAAPD GAPASGTSEP GRARGAGVCK SRPLDLVFII DSSRSVRPLE FTKVKTFVSR IIDTLDIGPA DTRVAVVNYA STVKIEFQLQ AYTDKQSLKQ AVGRITPLST GTMSGLAIQT AMDEAFTVEA GAREPSSNIP KVAIIVTDGR PQDQVNEVAA RAQASGIELY AVGVDRADMA SLKMMASEPL EEHVFYVETY GVIEKLSSRF QETFCALDPC VLGTHQCQHV CISDGEGKHH CECSQGYTLN ADKKTCSALD RCALNTHGCE HICVNDRSGS YHCECYEGYT LNEDRKTCSA QDKCALGTHG CQHICVNDRT GSHHCECYEG YTLNADKKTC SVRDKCALGS HGCQHICVSD GAASYHCDCY PGYTLNEDKK TCSATEEARR LVSTEDACGC EATLAFQDKV SSYLQRLNTK LDDILEKLKI NEYGQIHR
3D Structure
ModBase 3D Structure for O15232
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MATN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MATN3 recombinant protein
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia.
NCBI/Uniprot data below describe general gene information for MATN3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002372.1
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NCBI GenBank Nucleotide #
NM_002381.4
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UniProt Primary Accession #
O15232
[Other Products]
UniProt Secondary Accession #
Q4ZG02; B2CPU0[Other Products]
UniProt Related Accession #
O15232[Other Products]
Molecular Weight
48,317 Da
NCBI Official Full Name
matrilin-3
NCBI Official Synonym Full Names
matrilin 3
NCBI Official Symbol
MATN3??[Similar Products]
NCBI Official Synonym Symbols
HOA; OS2; EDM5; DIPOA; OADIP
??[Similar Products]
NCBI Protein Information
matrilin-3
UniProt Protein Name
Matrilin-3
UniProt Gene Name
MATN3??[Similar Products]
NCBI Summary for MATN3
This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for MATN3
Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
Research Articles on MATN3
1. our results revealed miR-483-5p directly targeted to the cartilage matrix protein matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
