LAMM; laminin M; laminin alpha-2; merosin heavy chain

For Research Use Only. Not for use in diagnostic procedures.

LAMA2 antibody detects endogenous levels of total LAMA2 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-LAMA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:20000

Peptide-+

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human placenta tissue using LAMA2 antibody. Immunofluorescence analysis of NIH/3T3 cells, using LAMA2 antibody.

343,905 Da

laminin subunit alpha 2

laminin subunit alpha-2

Laminin subunit alpha-2

LAMM??[Similar Products]

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Vuolteenaho R., J. Cell Biol. 124:381-394(1994). Ehrig K., . Natl. Acad. Sci. U.S.A. 87:3264-3268(1990). Liu T., J. Proteome Res. 4:2070-2080(2005).

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