Full Product Name
LAMA2 Antibody
Product Synonym Names
Laminin subunit alpha-2; Laminin M chain; Merosin heavy chain; LAMA2; LAMM
Product Gene Name
anti-LAMA2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P24043
Species Reactivity
Human, Mouse
Specificity
LAMA2 Antibody detects endogenous levels of total LAMA2 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human LAMA2.
Immunogen Range
2011-2060
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-LAMA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LAMA2 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-LAMA2 antibody
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:20000
Immunofluorescence (IF) of anti-LAMA2 antibody
Immunofluorescence analysis of NIH/3T3 cells, using LAMA2 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry (IHC) of anti-LAMA2 antibody
Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using LAMA2 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for LAMA2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000417.2
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NCBI GenBank Nucleotide #
NP_000417.2
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UniProt Primary Accession #
P24043
[Other Products]
UniProt Secondary Accession #
Q14736; Q5VUM2; Q93022[Other Products]
UniProt Related Accession #
P24043[Other Products]
NCBI Official Full Name
laminin subunit alpha-2 isoform a
NCBI Official Synonym Full Names
laminin subunit alpha 2
NCBI Official Symbol
LAMA2??[Similar Products]
NCBI Official Synonym Symbols
LAMM
??[Similar Products]
NCBI Protein Information
laminin subunit alpha-2
UniProt Protein Name
Laminin subunit alpha-2
UniProt Synonym Protein Names
Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain
UniProt Gene Name
LAMA2??[Similar Products]
UniProt Synonym Gene Names
LAMM??[Similar Products]
NCBI Summary for LAMA2
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for LAMA2
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Research Articles on LAMA2
1. Using high-throughput technology identify LAMA-2 as a candidate medullary sponge kidney disease biomarker possibly employable in future for the early diagnosis of this disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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