Full Product Name
Rabbit RPL11 Antibody
Product Gene Name
anti-RPL11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (24018269..24022915). Location: 1p36.1-p35
3D Structure
ModBase 3D Structure for P62913
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-RPL11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RPL11 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for RPL11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000966.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000975.3
[Other Products]
UniProt Primary Accession #
P62913
[Other Products]
UniProt Secondary Accession #
P25121; P39026; Q8TDH2; Q9Y674[Other Products]
UniProt Related Accession #
P62913[Other Products]
Molecular Weight
20,252 Da
NCBI Official Full Name
60S ribosomal protein L11 isoform 1
NCBI Official Synonym Full Names
ribosomal protein L11
NCBI Official Symbol
RPL11??[Similar Products]
NCBI Official Synonym Symbols
L11; DBA7; GIG34
??[Similar Products]
NCBI Protein Information
60S ribosomal protein L11; CLL-associated antigen KW-12; cell growth-inhibiting protein 34
UniProt Protein Name
60S ribosomal protein L11
UniProt Synonym Protein Names
CLL-associated antigen KW-12
Protein Family
50S ribosomal protein
UniProt Gene Name
RPL11??[Similar Products]
UniProt Entry Name
RL11_HUMAN
NCBI Summary for RPL11
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
UniProt Comments for RPL11
RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Motility/polarity/chemotaxis; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 1p36.1-p35
Cellular Component: membrane; cytoplasm; nucleolus; cytosol
Molecular Function: rRNA binding; protein binding; structural constituent of ribosome; RNA binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; ribosomal large subunit biogenesis and assembly; translational termination; viral infectious cycle; cellular protein metabolic process; translational elongation; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; rRNA processing; protein targeting
Disease: Diamond-blackfan Anemia 7
Research Articles on RPL11
1. disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress
Precautions
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Disclaimer
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