Product Name
RPL11, cDNA Clone
Product Synonym Names
DBA7; GIG34; L11
Product Gene Name
RPL11 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Nucleotide Sequence: ATGGCGCAGG ATCAAGGTGA AAAGGAGAAC CCCATGCGGG AACTTCGCAT CCGCAAACTC TGTCTCAACA TCTGTGTTGG GGAGAGTGGA GACAGACTGA CGCGAGCAGC CAAGGTGTTG GAGCAGCTCA CAGGGCAGAC CCCTGTGTTT TCCAAAGCTA GATACACTGT CAGATCCTTT GGCATCCGGA GAAATGAAAA GATTGCTGTC CACTGCACAG TTCGAGGGGC CAAGGCAGAA GAAATCTTGG AGAAGGGTCT AAAGGTGCGG GAGTATGAGT TAAGAAAAAA CAACTTCTCA GATACTGGAA ACTTTGGTTT TGGGATCCAG GAACACATCG ATCTGGGTAT CAAATATGAC CCAAGCATTG GTATCTACGG CCTGGACTTC TATGTGGTGC TGGGTAGGCC AGGTTTCAGC ATCGCAGACA AGAAGCGCAG GACAGGCTGC ATTGGGGCCA AACACAGAAT CAGCAAAGAG GAGGCCATGC GCTGGTTCCA GCAGAAGTAT GATGGGATCA TCCTTCCTGG CAAATAA
Trans lation Sequence: MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC IGAKHRISKE EAMRWFQQKY DGIILPGK
3D Structure
ModBase 3D Structure for P62913
Chromosome Location
1p36.1-p35
OMIM Reference Number
604175
Vector Description
This shuttle vector contains the complete ORF. It is inseted Nde I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
Preparation and Storage
Store the plasmid at -20 degree C.
Other Notes
Small volumes of RPL11 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RPL11 cdna clone
RPL11 is a ribosomal protein that is a component of the 60S subunit and belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. RPL11 probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for RPL11.
Product Categories/Family for RPL11 cdna clone
Epigenomics (Transcription & Translation)
NCBI/Uniprot data below describe general gene information for RPL11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000966.2
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NCBI GenBank Nucleotide #
NM_000975.3
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UniProt Primary Accession #
P62913
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UniProt Related Accession #
P62913[Other Products]
NCBI Official Full Name
60S ribosomal protein L11 isoform 1
NCBI Official Synonym Full Names
ribosomal protein L11
NCBI Official Symbol
RPL11??[Similar Products]
NCBI Official Synonym Symbols
L11; uL5; DBA7; GIG34
??[Similar Products]
NCBI Protein Information
60S ribosomal protein L11
UniProt Protein Name
60S ribosomal protein L11
UniProt Synonym Protein Names
CLL-associated antigen KW-12
Protein Family
50S ribosomal protein
UniProt Gene Name
RPL11??[Similar Products]
UniProt Entry Name
RL11_HUMAN
NCBI Summary for RPL11
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
UniProt Comments for RPL11
RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Motility/polarity/chemotaxis; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 1p36.1-p35
Cellular Component: membrane; cytoplasm; nucleolus; cytosol
Molecular Function: rRNA binding; protein binding; structural constituent of ribosome; RNA binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; ribosomal large subunit biogenesis and assembly; translational termination; viral infectious cycle; cellular protein metabolic process; translational elongation; translational initiation; mRNA catabolic process, nonsense-mediated decay; viral transcription; gene expression; rRNA processing; protein targeting
Disease: Diamond-blackfan Anemia 7
Research Articles on RPL11
1. patients with RPL11 mutations were less likely to need chronic treatment. Birth defects, including cardiac, skeletal, hand, cleft lip or palate and genitourinary malformations, also varied among the various genetic groups
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