Product Name
GRAF (OPHN1L) (ARHGAP26), Blocking Peptide
Full Product Name
GRAF (OPHN1L) Antibody (Center) Blocking peptide
Product Synonym Names
Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26; ARHGAP26; GRAF; KIAA0621; OPHN1L
Product Gene Name
ARHGAP26 blocking peptide
[Similar Products]
Product Synonym Gene Name
GRAF; KIAA0621; OPHN1L[Similar Products]
Antibody/Peptide Pairs
GRAF (OPHN1L) peptide (MBS9227525) is used for blocking the activity of GRAF (OPHN1L) antibody (MBS9208708)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UNA1
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human OPHN1L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note: Colocalizes with actin stress fibers and cortical actin structures.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ARHGAP26 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ARHGAP26 blocking peptide
GTPase-activating protein for RHOA and CDC42.
NCBI/Uniprot data below describe general gene information for ARHGAP26. It may not necessarily be applicable to this product.
NCBI Accession #
Q9UNA1.1
[Other Products]
UniProt Primary Accession #
Q9UNA1
[Other Products]
UniProt Secondary Accession #
O75117; Q5D035; Q9BYS6; Q9BYS7; Q9UJ00[Other Products]
UniProt Related Accession #
Q9UNA1[Other Products]
Molecular Weight
86,165 Da
NCBI Official Full Name
Rho GTPase-activating protein 26
NCBI Official Synonym Full Names
Rho GTPase activating protein 26
NCBI Official Symbol
ARHGAP26??[Similar Products]
NCBI Official Synonym Symbols
GRAF; GRAF1; OPHN1L; OPHN1L1
??[Similar Products]
NCBI Protein Information
rho GTPase-activating protein 26
UniProt Protein Name
Rho GTPase-activating protein 26
UniProt Synonym Protein Names
GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26
Protein Family
Rho GTPase-activating protein
UniProt Gene Name
ARHGAP26??[Similar Products]
UniProt Synonym Gene Names
GRAF; KIAA0621; OPHN1L??[Similar Products]
UniProt Entry Name
RHG26_HUMAN
NCBI Summary for ARHGAP26
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for ARHGAP26
ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Rac/Rho; Oncoprotein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: cytosol
Molecular Function: GTPase activator activity; phospholipid binding; protein binding
Biological Process: regulation of small GTPase mediated signal transduction
Disease: Juvenile Myelomonocytic Leukemia
Research Articles on ARHGAP26
1. GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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