Full Product Name
GRAF Rabbit Polyclonal
Product Gene Name
anti-GRAF antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Rho GTPase activating protein 26
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GRAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GRAF antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for GRAF. It may not necessarily be applicable to this product.
NCBI Accession #
AAM61871.1
[Other Products]
UniProt Secondary Accession #
O75117; Q5D035; Q9BYS6; Q9BYS7; Q9UJ00[Other Products]
UniProt Related Accession #
Q9UNA1[Other Products]
Molecular Weight
86,165 Da
NCBI Official Full Name
GRAF, partial
NCBI Official Synonym Full Names
Rho GTPase activating protein 26
NCBI Official Symbol
ARHGAP26??[Similar Products]
NCBI Official Synonym Symbols
GRAF; GRAF1; OPHN1L; OPHN1L1
??[Similar Products]
NCBI Protein Information
rho GTPase-activating protein 26
UniProt Protein Name
Rho GTPase-activating protein 26
UniProt Synonym Protein Names
GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26
UniProt Gene Name
ARHGAP26??[Similar Products]
UniProt Synonym Gene Names
GRAF; KIAA0621; OPHN1L??[Similar Products]
UniProt Entry Name
RHG26_HUMAN
NCBI Summary for GRAF
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for GRAF
ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; GAPs, Rac/Rho; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: cytoskeleton; cytosol; focal adhesion
Molecular Function: GTPase activator activity; phospholipid binding; protein binding
Biological Process: actin cytoskeleton organization and biogenesis; nervous system development; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Disease: Juvenile Myelomonocytic Leukemia
Research Articles on GRAF
1. GRAF expression is a favorable prognostic marker in patients with acute myeloid leukemia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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