Rabbit Polyclonal to Human ARHGAP26/GRAF; ARHGAP26; GRAF; KIAA0621; GRAF1; OPHN1L; Oligophrenin-1-like protein; OPHN1L1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Human ARHGAP26/GRAF. This antibody is expected to recognise both reported isoforms.

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Store at -20 degree C.
Avoid freeze-thaw cycles.

Small volumes of anti-ARHGAP26/GRAF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Interaction of a cell with the extracellular matrix triggers integrincell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved inthese cascades is focal adhesion kinase. the protein encoded by thisgene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42.Defects in this gene are a cause of juvenile myelomonocytic leukemia(JMML).

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 1:64000
IHC-P: 3.75 ug/ml
WB: 0.3-1 ug/ml

Anti-ARHGAP26/GRAF antibody IHC staining of human colon, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Antibody (0.3 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

86,165 Da

Rho GTPase activating protein 26

rho GTPase-activating protein 26

Rho GTPase-activating protein 26

GRAF; KIAA0621; OPHN1L??[Similar Products]

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

GTPase-activating protein for RHOA and CDC42.

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