SH3 domain-binding protein 2; 3BP-2; SH3BP2; 3BP2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This SH3BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human SH3BP2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.3 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SH3BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene has an N-terminal
pleckstrin homology (PH) domain, an SH3-binding proline-rich
region, and a C-terminal SH2 domain. The protein binds to the SH3
domains of several proteins including the ABL1 and SYK protein
tyrosine kinases, and functions as a cytoplasmic adaptor protein
to positively regulate transcriptional activity in T, natural
killer (NK), and basophilic cells. Mutations in this gene result in
cherubism. Multiple transcript variants encoding different isoforms
have been found for this gene.

Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

SH3BP2 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the SH3BP2 antibody detected the SH3BP2 protein (arrow).

62244

SH3-domain binding protein 2

SH3 domain-binding protein 2

SH3 domain-binding protein 2

3BP2; 3BP-2??[Similar Products]

3BP2_HUMAN

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

SH3BP2: an adaptor protein that binds differentially to the SH3 domains of certain proteins. Links the hemopoietic tyrosine kinase Fes to the cytoplasmic membrane in a phosphorylation dependent manner. Regulates FC-epsilon RI -mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Defects in 3BP2 are the cause of cherubism, an autosomal dominant inherited syndrome. Two differentially spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4p16.3

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: positive regulation of signal transduction; signal transduction

Disease: Cherubism

Lietman, S.A., et al. J. Orthop. Res. 28(11):1425-1430(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Amaral, F.R., et al. J. Oral Pathol. Med. 39(3):269-274(2010)
Shukla, U., et al. J. Biol. Chem. 284(49):33719-33728(2009)

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