Product Name
CIRH1A, Polyclonal Antibody
Full Product Name
Anti-CIRH1A Antibody
Product Synonym Names
KIAA1988; UTP4; Cirhin
Product Gene Name
anti-CIRH1A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q969X6
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of CIRH1A protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human CIRH1A
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CIRH1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CIRH1A antibody
Rabbit polyclonal antibody to CIRH1A
Applications Tested/Suitable for anti-CIRH1A antibody
Western Blot (WB)
Application Notes for anti-CIRH1A antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-CIRH1A antibody
Western blot analysis of CIRH1A expression in Hela (A), K562 (B), mouse liver (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for CIRH1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_116219.2
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NCBI GenBank Nucleotide #
NM_032830.2
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UniProt Primary Accession #
Q969X6
[Other Products]
UniProt Secondary Accession #
Q8NCD9; Q8TF14; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6[Other Products]
UniProt Related Accession #
Q969X6[Other Products]
Molecular Weight
69,639 Da
NCBI Official Full Name
U3 small nucleolar RNA-associated protein 4 homolog isoform 1
NCBI Official Synonym Full Names
UTP4, small subunit processome component
NCBI Official Symbol
UTP4??[Similar Products]
NCBI Official Synonym Symbols
NAIC; CIRH1A; CIRHIN; TEX292
??[Similar Products]
NCBI Protein Information
U3 small nucleolar RNA-associated protein 4 homolog
UniProt Protein Name
U3 small nucleolar RNA-associated protein 4 homolog
UniProt Synonym Protein Names
Cirhin; UTP4 small subunit processome component
UniProt Gene Name
UTP4??[Similar Products]
NCBI Summary for CIRH1A
This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for CIRH1A
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766). May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (PubMed:19732766).
Research Articles on CIRH1A
1. Results show that CIRH1A was highly expressed in carcinoma samples and colorectal cancer cells and suggest that CIRH1A plays a critical role in the proliferation, cell cycle distribution, and apoptosis of human malignant colorectal cells.
Precautions
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Disclaimer
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