Product Name
CYP51A1, Polyclonal Antibody
Full Product Name
CYP51A1 Antibody
Product Synonym Names
CP51; CYP51; CYPL1; LDM; P450-14DM; P450L1
Product Gene Name
anti-CYP51A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of CYP51A1
Calculated Molecular Weight: 509aa; 57kd
Observed Molecular Weight: 57kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CYP51A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CYP51A1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CYP51A1 antibody
WB: 1:500-1:5000
Testing Data of anti-CYP51A1 antibody
NCBI/Uniprot data below describe general gene information for CYP51A1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH18429.1
[Other Products]
UniProt Secondary Accession #
O00770; O00772; Q16784; Q8N1A8; Q99868; A4D1F8; B2RAI4; B4DJ55[Other Products]
UniProt Related Accession #
Q16850[Other Products]
Molecular Weight
46,312 Da
NCBI Official Full Name
CYP51A1 protein, partial
NCBI Official Synonym Full Names
cytochrome P450, family 51, subfamily A, polypeptide 1
NCBI Official Symbol
CYP51A1??[Similar Products]
NCBI Official Synonym Symbols
LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM
??[Similar Products]
NCBI Protein Information
lanosterol 14-alpha demethylase; CYPLI; cytochrome P450 51A1; cytochrome P450, 51 (lanosterol 14-alpha-demethylase); cytochrome P450-14DM; cytochrome P45014DM; cytochrome P450LI
UniProt Protein Name
Lanosterol 14-alpha demethylase
UniProt Synonym Protein Names
CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase
UniProt Gene Name
CYP51A1??[Similar Products]
UniProt Synonym Gene Names
CYP51; LDM; Cytochrome P45014DM??[Similar Products]
UniProt Entry Name
CP51A_HUMAN
NCBI Summary for CYP51A1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for CYP51A1
CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; EC 1.14.13.70
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: sterol 14-demethylase activity; iron ion binding; heme binding
Biological Process: xenobiotic metabolic process; cholesterol biosynthetic process; sterol metabolic process; steroid biosynthetic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol
Research Articles on CYP51A1
1. Data show that forkhead transcription factor 4 (FoxO4) interacts with sterol regulatory element binding protein (SREBP)2 and hypoxia inducible factor (HIF)2alpha to modulate lanosterol 14alpha demethylase (CYP51) promoter activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
