Mouse Malcavernin (CCM2) ELISA kit; C7orf22; MGC4067; MGC4607; MGC74868; OSM; PP10187; malcavernin; cerebral cavernous malformation 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of CCM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9320806 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cerebral cavernous malformation 2 (CCM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CCM2. The ELISA analytical biochemical technique of the MBS9320806 kit is based on CCM2 antibody-CCM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CCM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CCM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

48,248 Da

cerebral cavernous malformation 2

malcavernin; osmosensing scaffold for MEKK3; cerebral cavernous malformation 2 homolog; cerebral cavernous malformations protein 2 homolog

Malcavernin

Osm??[Similar Products]

CCM2_MOUSE

CCM2: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock. Defects in CCM2 are the cause of cerebral cavernous malformations type 2 (CCM2). Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and are usually present clinically during the 3rd to 5th decades of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Cellular Component: protein complex; cytoplasm

Molecular Function: protein binding

Biological Process: pericardium development; blood vessel development; intercellular junction assembly and maintenance; venous blood vessel morphogenesis; vasculature development; in utero embryonic development; multicellular organism growth; heart development; vasculogenesis; inner ear development; endothelial cell development

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