Full Product Name
CCM2 Polyclonal Antibody
Product Synonym Names
OSM; C7orf22; PP10187
Product Gene Name
anti-CCM2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Immunogen
Recombinant protein of human CCM2
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-67675 / sc-67677 / sc-68412
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CCM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CCM2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CCM2 antibody
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Western Blot (WB) of anti-CCM2 antibody
Western blot analysis of extracts of various tissues, using CCM2 antibody.
Immunohistochemistry (IHC) of anti-CCM2 antibody
Immunohistochemistry of paraffin-embedded human liver using CCM2 antibody at dilution of1:100 (x40 lens).
Immunohistochemistry (IHC) of anti-CCM2 antibody
Immunohistochemistry of paraffin-embedded rat heart using CCM2 antibody at dilution of1:100 (x40 lens).
NCBI/Uniprot data below describe general gene information for CCM2. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NM_001167934.1
[Other Products]
UniProt Secondary Accession #
Q71RE5; Q8TAT4; A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551[Other Products]
UniProt Related Accession #
Q9BSQ5[Other Products]
NCBI Official Full Name
cerebral cavernous malformations 2 protein isoform 3
NCBI Official Synonym Full Names
CCM2 scaffolding protein
NCBI Official Symbol
CCM2??[Similar Products]
NCBI Official Synonym Symbols
OSM; C7orf22; PP10187
??[Similar Products]
NCBI Protein Information
cerebral cavernous malformations 2 protein
UniProt Protein Name
Cerebral cavernous malformations 2 protein
UniProt Synonym Protein Names
Malcavernin
Protein Family
Cerebral cavernous malformations protein
UniProt Gene Name
CCM2??[Similar Products]
UniProt Synonym Gene Names
C7orf22??[Similar Products]
UniProt Entry Name
CCM2_HUMAN
NCBI Summary for CCM2
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
UniProt Comments for CCM2
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock ().
Research Articles on CCM2
1. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1, CCM2/malcavernin and CCM3/PDCD10 not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.
Precautions
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Disclaimer
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