Product Name
MVP (MVK), Blocking Peptide
Product Synonym Names
Mevalonate kinase; MK; MVK
Product Gene Name
MVK blocking peptide
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Antibody/Peptide Pairs
MVP peptide (MBS9227611) is used for blocking the activity of MVK antibody (MBS9213888)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q03426
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human MVK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of MVK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MVK blocking peptide
May be a regulatory site in cholesterol biosynthetic pathway.
NCBI/Uniprot data below describe general gene information for MVK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000422
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NCBI GenBank Nucleotide #
NM_000431.3
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UniProt Primary Accession #
Q03426
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UniProt Related Accession #
Q03426[Other Products]
Molecular Weight
42,451 Da
NCBI Official Full Name
mevalonate kinase isoform a
NCBI Official Synonym Full Names
mevalonate kinase
NCBI Official Symbol
MVK??[Similar Products]
NCBI Official Synonym Symbols
MK; LRBP; MVLK; POROK3
??[Similar Products]
NCBI Protein Information
mevalonate kinase
UniProt Protein Name
Mevalonate kinase
Protein Family
Mevalonate kinase
UniProt Gene Name
MVK??[Similar Products]
UniProt Synonym Gene Names
MK??[Similar Products]
UniProt Entry Name
KIME_HUMAN
NCBI Summary for MVK
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for MVK
MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Protein type: Translation; RNA-binding; EC 2.7.1.36; Kinase, other; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: cytosol; peroxisome
Molecular Function: identical protein binding; mevalonate kinase activity; protein binding
Biological Process: cholesterol biosynthetic process; isoprenoid biosynthetic process; negative regulation of inflammatory response
Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
Research Articles on MVK
1. Wild-type MK and the variant V261A, which is associated with HIDS, were recombinantly expressed in Escherichia coli. Enzyme activity was determined by formation of MVAP over time
Precautions
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Disclaimer
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