Full Product Name
Mouse monoclonal MVK antibody
Product Synonym Names
MVK antibody
Product Gene Name
anti-MVK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Purified by affinity chromatography.
Form/Format
Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration
500 ug-1 mg/ml (lot specific)
Immunogen
MVK antibody was raised in mouse using a full length recombinant protein of human MVK (NP_000422) produced in HEK293T cells, as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-MVK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MVK antibody
Signal Transduction
Applications Tested/Suitable for anti-MVK antibody
Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-MVK antibody
IF: 1:100
WB: 1:2000
Immunofluorescence (IF) of anti-MVK antibody
Immunofluorescent staining of COS7 cells transiently transfected with recombinant MVK protein using MVK antibody
NCBI/Uniprot data below describe general gene information for MVK. It may not necessarily be applicable to this product.
NCBI Accession #
AKI69730.1
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UniProt Related Accession #
Q03426[Other Products]
Molecular Weight
42,451 Da
NCBI Official Full Name
MVK, partial
NCBI Official Synonym Full Names
mevalonate kinase
NCBI Official Symbol
MVK??[Similar Products]
NCBI Official Synonym Symbols
MK; LRBP; MVLK; POROK3
??[Similar Products]
NCBI Protein Information
mevalonate kinase
UniProt Protein Name
Mevalonate kinase
Protein Family
Mevalonate kinase
UniProt Gene Name
MVK??[Similar Products]
UniProt Synonym Gene Names
MK??[Similar Products]
NCBI Summary for MVK
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for MVK
MVK: May be a regulatory site in cholesterol biosynthetic pathway. Defects in MVK are the cause of mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
Protein type: EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: cytosol; peroxisome
Molecular Function: identical protein binding; mevalonate kinase activity; protein binding
Biological Process: cholesterol biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; negative regulation of inflammatory response
Disease: Hyper-igd Syndrome; Mevalonic Aciduria; Porokeratosis 3, Disseminated Superficial Actinic Type
Research Articles on MVK
1. These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of coronary heart disease by altering plasma HDL-C levels in Han Chinese.
Precautions
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