Product Name
G6PD, cDNA Clone
Popular Item
Full Product Name
G6PD cDNA Clone
Product Gene Name
G6PD cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcagagc aggtggccct gagccggacc caggtgtgcg ggatcctgcg ggaagagctt ttccagggcg atgccttcca tcagtcggat acacacatat tcatcatcat gggtgcatcg ggtgacctgg ccaagaagaa gatctacccc accatctggt ggctgttccg ggatggcctt ctgcccgaaa acaccttcat cgtgggctat gcccgttccc gcctcacagt ggctgacatc cgcaaacaga gtgagccctt cttcaaggcc accccagagg agaagctcaa gctggaggac ttctttgccc gcaactccta tgtggctggc cagtacgatg atgcagcctc ctaccagcgc ctcaacagcc acatgaatgc cctccacctg gggtcacagg ccaaccgcct cttctacctg gccttgcccc cgaccgtcta cgaggccgtc accaagaaca ttcacgagtc ctgcatgagc cagataggct ggaaccgcat catcgtggag aagcccttcg ggagggacct gcagagctct gaccggctgt ccaaccacat ctcctccctg ttccgtgagg accagatcta ccgcatcgac cactacctgg gcaaggagat ggtgcagaac ctcatggtgc tgagatttgc caacaggatc ttcggcccca tctggaaccg ggacaacatc gcctgcgtta tcctcacctt caaggagccc tttggcactg agggtcgcgg gggctatttc gatgaatttg ggatcatccg ggacgtgatg cagaaccacc tactgcagat gctgtgtctg gtggccatgg agaagcccgc ctccaccaac tcagatgacg tccgtgatga gaaggtcaag gtgttgaaat gcatctcaga ggtgcaggcc aacaatgtgg tcctgggcca gtacgtgggg aaccccgatg gagagggcga ggccaccaaa gggtacctgg acgaccccac ggtgccccgc gggtccacca ccgccacttt tgcagccgtc gtcctctatg tggagaatga gaggtgggat ggggtgccct tcatcctgcg ctgcggcaag gccctgaacg agcgcaaggc cgaggtgagg ctgcagttcc atgatgtggc cggcgacatc ttccaccagc agtgcaagcg caacgagctg gtgatccgcg tgcagcccaa cgaggccgtg tacaccaaga tgatgaccaa gaagccgggc atgttcttca accccgagga gtcggagctg gacctgacct acggcaacag atacaagaac gtgaagctcc ctgacgccta tgagcgcctc atcctggacg tcttctgcgg gagccagatg cacttcgtgc gcagcgacga gctccgtgag gcctggcgta ttttcacccc actgctgcac cagattgagc tggagaagcc caagcccatc ccctatattt atggcagccg aggccccacg gaggcagacg agctgatgaa gagagtgggt ttccagtatg agggcaccta caagtgggtg aacccccaca agctctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of G6PD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for G6PD. It may not necessarily be applicable to this product.
NCBI Accession #
BC000337
[Other Products]
UniProt Secondary Accession #
Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2; D3DWX9[Other Products]
UniProt Related Accession #
P11413[Other Products]
Molecular Weight
62,468 Da
NCBI Official Full Name
Homo sapiens glucose-6-phosphate dehydrogenase, mRNA
NCBI Official Synonym Full Names
glucose-6-phosphate dehydrogenase
NCBI Official Symbol
G6PD??[Similar Products]
NCBI Official Synonym Symbols
G6PD1
??[Similar Products]
NCBI Protein Information
glucose-6-phosphate 1-dehydrogenase
UniProt Protein Name
Glucose-6-phosphate 1-dehydrogenase
UniProt Gene Name
G6PD??[Similar Products]
UniProt Synonym Gene Names
G6PD??[Similar Products]
UniProt Entry Name
G6PD_HUMAN
NCBI Summary for G6PD
This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for G6PD
G6PD: glucose-6-phosphate dehydrogenase. A cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two splice variant isoforms have been described. The long isoform is found in lymphoblasts, granulocytes and sperm.
Protein type: EC 1.1.1.49; Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: centrosome; cytoplasm; cytosol; internal side of plasma membrane; intracellular membrane-bound organelle; membrane; microtubule organizing center
Molecular Function: glucose binding; glucose-6-phosphate dehydrogenase activity; identical protein binding; NADP binding; protein binding; protein homodimerization activity
Biological Process: cholesterol biosynthetic process; erythrocyte maturation; glucose 6-phosphate metabolic process; glutathione metabolic process; lipid metabolic process; NADP metabolic process; NADPH regeneration; pentose biosynthetic process; pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; ribose phosphate biosynthetic process; substantia nigra development
Disease: Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency; Favism, Susceptibility To; Malaria, Susceptibility To
Research Articles on G6PD
1. G6PD deficiency affects the cellular inflammatory response and the decreased TNF-alpha-mediated antiviral response in G6PD-kd A549 cells is a result of dysregulated NOX/MAPK/NF-kappaB/COX-2 signaling
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
