Full Product Name
ODPB Polyclonal Antibody
Product Synonym Names
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1; PDHB; PHE1B
Product Gene Name
anti-ODPB antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11177
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 160-240
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-ODPB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ODPB antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ODPB antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for ODPB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000916.2
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NCBI GenBank Nucleotide #
NM_000925.3
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UniProt Primary Accession #
P11177
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UniProt Secondary Accession #
Q6FH45; Q9BQ27; Q9UFK3; B2R7L0; B4DDD7[Other Products]
UniProt Related Accession #
P11177[Other Products]
NCBI Official Full Name
pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform 1
NCBI Official Synonym Full Names
pyruvate dehydrogenase E1 beta subunit
NCBI Official Symbol
PDHB??[Similar Products]
NCBI Official Synonym Symbols
PDHBD; PHE1B; PDHE1B; PDHE1-B
??[Similar Products]
NCBI Protein Information
pyruvate dehydrogenase E1 component subunit beta, mitochondrial
UniProt Protein Name
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
UniProt Gene Name
PDHB??[Similar Products]
UniProt Synonym Gene Names
PHE1B; PDHE1-B??[Similar Products]
NCBI Summary for ODPB
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
UniProt Comments for ODPB
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle.
Research Articles on ODPB
1. PDHB was downregulated in nasopharyngeal carcinoma cells. Forced expression of PDHB in NPC cells inhibited cell growth and migration, while knocking down the expression of PDHB promoted the growth, migration, and tumorigenesis of NPC cells. PDHB inhibited ERK signaling and cell growth driven by RasV12.
Precautions
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Disclaimer
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