Human Magnesium transporter NIPA4 (NIPAL4) ELISA kit; ICHTHYIN; ICHYN; NIPA-like 4; ichthyin protein; NIPA-like domain containing 4

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of NIPAL4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328102 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the NIPA-like domain containing 4 (NIPAL4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NIPAL4. The ELISA analytical biochemical technique of the MBS9328102 kit is based on NIPAL4 antibody-NIPAL4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NIPAL4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NIPAL4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

50,058 Da

NIPA-like domain containing 4

magnesium transporter NIPA4; NIPA-like protein 4; non-imprinted in Prader-Willi/Angelman syndrome region protein 4

Magnesium transporter NIPA4

ICHN; NIPA4??[Similar Products]

NIPA4_HUMAN

This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]

ICHN: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII). ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis). Belongs to the NIPA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: integral to membrane

Molecular Function: magnesium ion transmembrane transporter activity

Biological Process: magnesium ion transport

Disease: Ichthyosis, Congenital, Autosomal Recessive 6

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