Product Name
DCTN4, Blocking Peptide
Full Product Name
DCTN4 Antibody (N-term) Blocking peptide
Product Synonym Names
Dynactin subunit 4; Dyn4; Dynactin subunit p62; DCTN4
Product Gene Name
DCTN4 blocking peptide
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Antibody/Peptide Pairs
DCTN4 peptide (MBS9219919) is used for blocking the activity of DCTN4 antibody (MBS9205642)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UJW0
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of DCTN4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note: In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of DCTN4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DCTN4 blocking peptide
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
NCBI/Uniprot data below describe general gene information for DCTN4. It may not necessarily be applicable to this product.
NCBI Accession #
Q9UJW0.1
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UniProt Primary Accession #
Q9UJW0
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UniProt Secondary Accession #
Q8TAN8; B3KWW0; D3DQH0; E5RGT5[Other Products]
UniProt Related Accession #
Q9UJW0[Other Products]
Molecular Weight
53,152 Da
NCBI Official Full Name
Dynactin subunit 4
NCBI Official Synonym Full Names
dynactin subunit 4
NCBI Official Symbol
DCTN4??[Similar Products]
NCBI Official Synonym Symbols
P62; DYN4
??[Similar Products]
NCBI Protein Information
dynactin subunit 4
UniProt Protein Name
Dynactin subunit 4
UniProt Synonym Protein Names
Dynactin subunit p62
UniProt Gene Name
DCTN4??[Similar Products]
UniProt Synonym Gene Names
Dyn4??[Similar Products]
UniProt Entry Name
DCTN4_HUMAN
UniProt Comments for DCTN4
dynactin 4: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton. Belongs to the dynactin subunit 4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor; Microtubule-binding
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; dynactin complex; nucleus
Molecular Function: protein binding; protein N-terminus binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; ER to Golgi vesicle-mediated transport; nuclear migration
Research Articles on DCTN4
1. used an extreme phenotype study to discover that variants in DCTN4, encoding a dynactin protein, are associated with time to first P. aeruginosa airway infection, chronic P. aeruginosa infection and mucoid P. aeruginosa in individuals with cystic fibrosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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