Product Name
DCTN4, Polyclonal Antibody
Popular Item
Full Product Name
DCTN4 Antibody
Product Synonym Names
DCTN 4; Dctn4; DCTN4_HUMAN; Dynactin 4 (p62); Dynactin 4; Dynactin p62 subunit; Dynactin subunit 4; Dynactin subunit p62; Dynactin4; p62
Product Gene Name
anti-DCTN4 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UJW0
Species Reactivity
Human, Mouse, Rat
Specificity
DCTN4 antibody detects endogenous levels of total DCTN4
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human DCTN4
Subcellular Location
Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Centrosome. Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.
Predicted Cross Reactivity
Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Similarity
Pig (100%), Zebrafish (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-DCTN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DCTN4 antibody
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Subunit Structure: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).
Similarity: Belongs to the dynactin subunit 4 family.
Applications Tested/Suitable for anti-DCTN4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DCTN4 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-DCTN4 antibody
Western blot analysis of DCTN4 using COLO205 whole cell lysates
NCBI/Uniprot data below describe general gene information for DCTN4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129115.1
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NCBI GenBank Nucleotide #
NM_001135643.1
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UniProt Primary Accession #
Q9UJW0
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UniProt Secondary Accession #
Q8TAN8; B3KWW0; D3DQH0; E5RGT5[Other Products]
UniProt Related Accession #
Q9UJW0[Other Products]
Molecular Weight
Observed: 52 kDa
Predicted: 53 kDa
NCBI Official Full Name
dynactin subunit 4 isoform a
NCBI Official Synonym Full Names
dynactin subunit 4
NCBI Official Symbol
DCTN4??[Similar Products]
NCBI Official Synonym Symbols
P62; DYN4
??[Similar Products]
NCBI Protein Information
dynactin subunit 4
UniProt Protein Name
Dynactin subunit 4
UniProt Synonym Protein Names
Dynactin subunit p62
UniProt Gene Name
DCTN4??[Similar Products]
UniProt Synonym Gene Names
Dyn4??[Similar Products]
UniProt Comments for DCTN4
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Research Articles on DCTN4
1. Findings provide evidence that DCTN4 missense variants, especially p.Tyr263Cys, may be involved in the pathogenesis of chronic Pseudomonas aeruginosa infection in male with cystic fi brosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
