Full Product Name
DSC3 antibody - N-terminal region
Product Gene Name
anti-DSC3 antibody
[Similar Products]
Product Synonym Gene Name
CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP[Similar Products]
Antibody/Peptide Pairs
DSC3 peptide (MBS3232644) is used for blocking the activity of DSC3 antibody (MBS3207678)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: MQENSLGPFP LFLQQVESDA AQNYTVFYSI SGRGVDKEPL NLFYIERDTG
3D Structure
ModBase 3D Structure for Q14574
Species Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 93%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 93%; Rat: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human DSC3
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-DSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSC3 antibody
This is a rabbit polyclonal antibody against DSC3. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: DSC3 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
Product Categories/Family for anti-DSC3 antibody
Polyclonal; Signal Proteins; Cell Adhesion; Membrane Protein;
Applications Tested/Suitable for anti-DSC3 antibody
Western Blot (WB)
Western Blot (WB) of anti-DSC3 antibody
WB Suggested Anti-DSC3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
NCBI/Uniprot data below describe general gene information for DSC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001932
[Other Products]
NCBI GenBank Nucleotide #
NM_001941
[Other Products]
UniProt Primary Accession #
Q14574
[Other Products]
UniProt Related Accession #
Q14574[Other Products]
NCBI Official Full Name
desmocollin-3 isoform Dsc3a preproprotein
NCBI Official Synonym Full Names
desmocollin 3
NCBI Official Symbol
DSC3??[Similar Products]
NCBI Official Synonym Symbols
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
??[Similar Products]
NCBI Protein Information
desmocollin-3
UniProt Protein Name
Desmocollin-3
UniProt Synonym Protein Names
Cadherin family member 3; Desmocollin-4; HT-CP
Protein Family
Desmocollin
UniProt Gene Name
DSC3??[Similar Products]
UniProt Synonym Gene Names
CDHF3; DSC4??[Similar Products]
UniProt Entry Name
DSC3_HUMAN
NCBI Summary for DSC3
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Research Articles on DSC3
1. The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism.
Precautions
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Disclaimer
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