Full Product Name
DSC3 Polyclonal Antibody
Product Synonym Names
Desmocollin-3; Cadherin family member 3; Desmocollin-4; HT-CP; DSC3; CDHF3; DSC4
Product Gene Name
anti-DSC3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14574
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-DSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DSC3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DSC3 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for DSC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001932.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001941.4
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UniProt Primary Accession #
Q14574
[Other Products]
UniProt Secondary Accession #
Q14200; Q9HAZ9; A6NN35[Other Products]
UniProt Related Accession #
Q14574[Other Products]
NCBI Official Full Name
desmocollin-3 isoform Dsc3a preproprotein
NCBI Official Synonym Full Names
desmocollin 3
NCBI Official Symbol
DSC3??[Similar Products]
NCBI Official Synonym Symbols
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
??[Similar Products]
NCBI Protein Information
desmocollin-3
UniProt Protein Name
Desmocollin-3
UniProt Synonym Protein Names
Cadherin family member 3; Desmocollin-4; HT-CP
Protein Family
Desmocollin
UniProt Gene Name
DSC3??[Similar Products]
UniProt Synonym Gene Names
CDHF3; DSC4??[Similar Products]
NCBI Summary for DSC3
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for DSC3
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Research Articles on DSC3
1. The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism.
Precautions
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Disclaimer
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