Product Name
Desmocollin-3 (DSC3), Recombinant Protein
Full Product Name
Recombinant Human Desmocollin-3 (DSC3), partial
Product Gene Name
DSC3 recombinant protein
[Similar Products]
Product Synonym Gene Name
DSC3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
136-690
Sequence
RWAPI PCSMQENSLG PFPLFLQQVE SDAAQNYTVF YSISGRGVDK EPLNLFYIER DTGNLFCTRP VDREEYDVFD LIAYASTADG YSADLPLPLP IRVEDENDNH PVFTEAIYNF EVLESSRPGT TVGVVCATDR DEPDTMHTRL KYSILQQTPR SPGLFSVHPS TGVITTVSHY LDREVVDKYS LIMKVQDMDG QFFGLIGTST CIITVTDSND NAPTFRQNAY EAFVEENAFN VEILRIPIED KDLINTANWR VNFTILKGNE NGHFKISTDK ETNEGVLSVV KPLNYEENRQ VNLEIGVNNE APFARDIPRV TALNRALVTV HVRDLDEGPE CTPAAQYVRI KENLAVGSKI NGYKAYDPEN RNGNGLRYKK LHDPKGWITI DEISGSIITS KILDREVETP KNELYNITVL AIDKDDRSCT GTLAVNIEDV NDNPPEILQE YVVICKPKMG YTDILAVDPD EPVHGAPFYF SLPNTSPEIS RLWSLTKVND TAARLSYQKN AGFQEYTIPI TVKDRAGQAA TKLLRVNLCE CTHPTQCRAT SRSTGVILGK
3D Structure
ModBase 3D Structure for Q14574
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DSC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DSC3 recombinant protein
This protein is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.
NCBI/Uniprot data below describe general gene information for DSC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001932.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001941.4
[Other Products]
UniProt Primary Accession #
Q14574
[Other Products]
UniProt Secondary Accession #
Q14200; Q9HAZ9; A6NN35[Other Products]
UniProt Related Accession #
Q14574[Other Products]
Molecular Weight
93,454 Da
NCBI Official Full Name
desmocollin-3 isoform Dsc3a preproprotein
NCBI Official Synonym Full Names
desmocollin 3
NCBI Official Symbol
DSC3??[Similar Products]
NCBI Official Synonym Symbols
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
??[Similar Products]
NCBI Protein Information
desmocollin-3
UniProt Protein Name
Desmocollin-3
UniProt Synonym Protein Names
Cadherin family member 3; Desmocollin-4; HT-CP
Protein Family
Desmocollin
UniProt Gene Name
DSC3??[Similar Products]
UniProt Synonym Gene Names
CDHF3; DSC4??[Similar Products]
NCBI Summary for DSC3
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for DSC3
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Research Articles on DSC3
1. The Findings of this study imply early alteration of the substantia nigra in XDP mutation carriers prone to develop parkinsonism.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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