Product Name
Desmocollin 3 (DSC3), Monoclonal Antibody
Full Product Name
MAb to Desmocollin 3
Product Synonym Names
Monoclonal Antibody to Human Desmocollin 3
Product Gene Name
anti-DSC3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 18; NC_000018.9 (28570052..28622781, complement). Location: 18q12.1
3D Structure
ModBase 3D Structure for Q14574
Host
Host: Mouse
Source: Cell Culture
Specificity
Desmocollin 3
MAb localizes Dsc3 present in all living epidermal layers, in glandular duct cells, in basal matrix cells and outer root sheath of hair follicles, basal and suprabasal cell layers of stratified epithelia (e.g. vagina, tongue, esophagus),
Form/Format
Supernatant, Liquid
Immunogen
Synthetic peptide corresponding to a sequence present on the extracellular anchor domain of human desmocollin 3 (VHGAPFYFSLPNTSPEISRLWSLTKVC)
Affinity Constant
Not determined
Preservative
0.09% Sodium azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Store at 2 to 8 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-DSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-DSC3 antibody
Monoclonal Antibodies to Proteins and Bioactive Peptides
Applications Tested/Suitable for anti-DSC3 antibody
Immunohistochemistry - Formalin/Paraffin, Western Blot
NCBI/Uniprot data below describe general gene information for DSC3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077741.2
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NCBI GenBank Nucleotide #
NM_024423.2
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UniProt Primary Accession #
Q14574
[Other Products]
UniProt Secondary Accession #
Q14200; Q9HAZ9; A6NN35[Other Products]
UniProt Related Accession #
Q14574; Q9HAX1[Other Products]
Molecular Weight
99,969 Da[Similar Products]
NCBI Official Full Name
desmocollin-3 isoform Dsc3b preproprotein
NCBI Official Synonym Full Names
desmocollin 3
NCBI Official Symbol
DSC3??[Similar Products]
NCBI Official Synonym Symbols
DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP
??[Similar Products]
NCBI Protein Information
desmocollin-3; desmocollin-4; cadherin family member 3
UniProt Protein Name
Desmocollin-3
UniProt Synonym Protein Names
Cadherin family member 3; Desmocollin-4; HT-CP
Protein Family
Desmocollin
UniProt Gene Name
DSC3??[Similar Products]
UniProt Synonym Gene Names
CDHF3; DSC4??[Similar Products]
UniProt Entry Name
DSC3_HUMAN
NCBI Summary for DSC3
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq]
UniProt Comments for DSC3
DSC3: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Defects in DSC3 are the cause of hypotrichosis and recurrent skin vesicles (HRSV). A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the boby. Mucosal vesicles are absent. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; membrane; cytoplasm; plasma membrane; extracellular region; integral to membrane; intercellular junction
Molecular Function: gamma-catenin binding; calcium ion binding
Biological Process: protein stabilization; in utero embryonic development; cell adhesion; homophilic cell adhesion
Disease: Brugada Syndrome 7
Product References and Citations for anti-DSC3 antibody
??Nuber, U.A., et al., (1996), "Patterns of desmocollin synthesis in human epithelia: Immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells", Eur. J. Cell Biol., 71, 1-13.
??Sch?fer, S., et al., (1996
Research Articles on DSC3
1. These findings demonstrate that IgG autoantibodies against an additional component of the desmosomes, Dsc3, induce loss of keratinocyte adhesion and thus may contribute to blister formation in pemphigus.
Precautions
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Disclaimer
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