Product Gene Name
anti-CD38 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (15779931..15850706). Location: 4p15
3D Structure
ModBase 3D Structure for P28907
Form/Format
CD38 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Tonsil, Lymph Node
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.
Other Notes
Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD38 antibody
CD38 is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been connected to HIV infection, Leukemias, Myelomas, solid tumors, Type II Diabetes Mellitus and bone metabolism, as well as some genetically-determined conditions. It has also been used as a prognostic marker in Leukemia. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages, and may be detected on cells from Multiple Myeloma, ALL (B and T) and some AML. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of Lymphomas and Leukemias, inhibition of B-lymphopoiesis, detection of plasma cells, protection of B-cells from apoptosis, and as a marker for activated B and T-cell proliferation.
Dilution Information of anti-CD38 antibody
Immunohistochemistry (IHC) of anti-CD38 antibody
NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P28907
[Other Products]
UniProt Secondary Accession #
O00121; O00122; Q96HY4[Other Products]
UniProt Related Accession #
P28907; Q4FCX6[Other Products]
Molecular Weight
34,328 Da
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38??[Similar Products]
NCBI Official Synonym Symbols
T10
??[Similar Products]
NCBI Protein Information
ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); OTTHUMP00000158633; OTTHUMP00000217743; NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38??[Similar Products]
UniProt Entry Name
CD38_HUMAN
NCBI Summary for CD38
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq]
UniProt Comments for CD38
Function: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Catalytic activity: NAD+ + H2O = ADP-ribose + nicotinamide.
Enzyme regulation: ATP inhibits the hydrolyzing activity.
Subcellular location: Membrane; Single-pass type II membrane protein.
Tissue specificity: Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Ref.2
Developmental stage: Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Sequence similarities: Belongs to the ADP-ribosyl cyclase family.
Research Articles on CD38
1. gene mutational status and CD38 expression correlated with good Methylation
Precautions
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Disclaimer
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