cd38; cd-38

For Research Use Only. Not for use in diagnostic procedures.

HEk293 Cells

>95%, as determined by SDS-PAGE and HPLC

Recombinant CD38 is supplied as a 0.2 um filtered PBS solution, pH7.2.

Recombinant CD38, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months.

Avoid repeated freeze/thaw cycles.

Small volumes of CD38 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Human CD38 is a broadly expressed type II transmembrane glycoprotein of ~45 kDa in its monomeric form. This consists of a short intracytoplasmic (IC) tail, a transmembrane domain and a major extracellular domain (ECD) formed by 256 of the 300 constituent amino acids of the CD38 polypeptide.The CD38 ECD, where both receptor and enzymatic activities reside, harbours a 12 cysteine/6 disulfide signature common to the members of this family.

Receptors CD

34,328 Da

ADP-ribosyl cyclase 1

cADPr hydrolase 1??[Similar Products]

CD38_HUMAN

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.99.20; Lyase; Hydrolase; Apoptosis; EC 3.2.2.6; Membrane protein, integral; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis

? the ac133+CD38–, but not the rhodamine-low, phenotype tracks ltc-ic and src function in human cord blood ex vivo expansion cultures .Blood, Jan 2010; 115: 257 - 260.
? CD38-mediated ca2+ signaling contributes to angiotensin ii-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation .J. Biol. Chem., Jan 2010; 285: 576 - 582.
? CD38 induces homing of chronic lymphocytic leukemia cells to the lymphoid organs through a functional interplay with cxcr4. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2328.
? CD38 expression on cd34+ cells as a single flow cytometric parameter to distinguish myelodysplastic syndromes (mds) from non-clonal cytopenias. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2783.
? CD38 cd49d are physically and functionally associated in b-cell chronic lymphocytic leukemia cells. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 357.