Product Name
Cyclin-Y (CCNY), Recombinant Protein
Full Product Name
Recombinant Human Cyclin-Y (CCNY)
Product Gene Name
CCNY recombinant protein
[Similar Products]
Product Synonym Gene Name
CCNY[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-341aa, Full Length of Mature Protein
Sequence
GNTTSCCVSS SPKLRRNAHS RLESYRPDTD LSREDTGCNL QHISDRENID DLNMEFNPSD HPRASTIFLS KSQTDVREKR KSLFINHHPP GQIARKYSSC STIFLDDSTV SQPNLKYTIK CVALAIYYHI KNRDPDGRML LDIFDENLHP LSKSEVPPDY DKHNPEQKQI YRFVRTLFSA AQLTAECAIV TLVYLERLLT YAEIDICPAN WKRIVLGAIL LASKVWDDQA VWNVDYCQIL KDITVEDMNE LERQFLELLQ FNINVPSSVY AKYYFDLRSL AEANNLSFPL EPLSRERAHK LEAISRLCED KYKDLRRSAR KRSASADNLT LPRWSPAIIS
3D Structure
ModBase 3D Structure for Q8ND76
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CCNY recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CCNY. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269781.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001282852.1
[Other Products]
UniProt Primary Accession #
Q8ND76
[Other Products]
UniProt Secondary Accession #
Q2M3V4; Q2TU96; Q6NT86; Q7Z4U7; Q8TEX2; Q8TEX3; Q96M99; Q96P45; B7ZKX9; D3DRY9[Other Products]
UniProt Related Accession #
Q8ND76[Other Products]
Molecular Weight
33,245 Da
NCBI Official Full Name
cyclin-Y isoform 3
NCBI Official Synonym Full Names
cyclin Y
NCBI Official Symbol
CCNY??[Similar Products]
NCBI Official Synonym Symbols
CCNX; CFP1; CBCP1; C10orf9
??[Similar Products]
NCBI Protein Information
cyclin-Y
UniProt Protein Name
Cyclin-Y
UniProt Synonym Protein Names
Cyclin box protein 1; Cyclin fold protein 1; cyclin-X
UniProt Gene Name
CCNY??[Similar Products]
UniProt Synonym Gene Names
C10orf9; CBCP1; CFP1; Cyc-Y??[Similar Products]
NCBI Summary for CCNY
Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
UniProt Comments for CCNY
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Research Articles on CCNY
1. findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
