Full Product Name
MeCP2 Antibody
Product Synonym Names
AUTSX3; DKFZp686A24160; MeCp-2 protein; MECP2; methyl CpG binding protein 2 (Rett syndrome)
Product Gene Name
anti-MeCP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51608
Specificity
MeCP2 rabbit polyclonal antibody detects endogenous MeCP2 proteins.
Purity/Purification
Affinity purification using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Target Name
MeCP2 Antibody
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-MeCP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MeCP2 antibody
Methyl-CpG-binding protein 2(MeCP2), whose exact function is unclear. It appears to help regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein usually regulates genes involved in brain function, even though this protein is found throughout the body.Within the brain, the MeCP2 protein is important for the function of nerve cells (neurons) and is present in high levels in mature neurons. This protein likely plays a role in maintaining connections (synapses) between neurons, where cell-to-cell communication occurs. Many of the genes that are known to be regulated by the MeCP2 protein play a role in normal brain function, particularly the maintenance of synapses.
Product Categories/Family for anti-MeCP2 antibody
Total protein Ab
Applications Tested/Suitable for anti-MeCP2 antibody
Western Blot (WB)
Application Notes for anti-MeCP2 antibody
Western blotting: 1:2000~1:5000
Western Blot (WB) of anti-MeCP2 antibody
Western blot analysis of Hela cell lysate, using diluted at 1:2,000 (lane 1) and 1:5,000 (lane 2).
NCBI/Uniprot data below describe general gene information for MeCP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001104262.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001110792.1
[Other Products]
UniProt Primary Accession #
P51608
[Other Products]
UniProt Secondary Accession #
O15233; Q6QHH9; Q7Z384[Other Products]
UniProt Related Accession #
P51608[Other Products]
Molecular Weight
53,323 Da
NCBI Official Full Name
methyl-CpG-binding protein 2 isoform 2
NCBI Official Synonym Full Names
methyl CpG binding protein 2
NCBI Official Symbol
MECP2??[Similar Products]
NCBI Official Synonym Symbols
RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13
??[Similar Products]
NCBI Protein Information
methyl-CpG-binding protein 2
UniProt Protein Name
Methyl-CpG-binding protein 2
Protein Family
Methyl-CpG-binding protein
UniProt Gene Name
MECP2??[Similar Products]
UniProt Synonym Gene Names
MeCp-2 protein; MeCp2??[Similar Products]
UniProt Entry Name
MECP2_HUMAN
NCBI Summary for MeCP2
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009]
UniProt Comments for MeCP2
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
Research Articles on MeCP2
1. CpG DNA methylation in MITF is important in the melanoma skin cancer development.
Precautions
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Disclaimer
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