Rat Metalloreductase STEAP3 (STEAP3) ELISA kit; STMP3; TSAP6; dudlin-2; 1010001D01Rik; OTTHUMP00000162093; dudlin 2; dudulin 2; six transmembrane prostate protein 3; tumor suppressor pHyde; STEAP family member 3

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of STEAP3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9324335 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the STEAP family member 3 (STEAP3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STEAP3. The ELISA analytical biochemical technique of the MBS9324335 kit is based on STEAP3 antibody-STEAP3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STEAP3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STEAP3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

54,674 Da

STEAP family member 3, metalloreductase

metalloreductase STEAP3; pHyde; tumor suppressor pHyde; six-transmembrane epithelial antigen of prostate 3

Metalloreductase STEAP3

STEA3_RAT

induces apoptosis; inhibits prostate tumor growth in some cell lines [RGD, Feb 2006]

STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II.

Protein type: Transporter, iron; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; Transporter; EC 1.16.1.-; Transporter, ion channel

Cellular Component: multivesicular body; cell; integral to membrane; plasma membrane; endosome membrane; endosome

Molecular Function: metal ion binding; ferric-chelate reductase activity; cupric reductase activity

Biological Process: iron ion homeostasis; positive regulation of apoptosis; apoptosis; protein secretion; copper ion import; iron ion transport

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