Product Name
ASPA, Blocking Peptide
Full Product Name
ASPA Peptide - middle region
Product Gene Name
ASPA blocking peptide
[Similar Products]
Product Synonym Gene Name
ACY2; ASP[Similar Products]
ASPA peptide (MBS3237491) is used for blocking the activity of ASPA antibody (MBS3212544)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P45381
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of ASPA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ASPA blocking peptide
This is a synthetic peptide designed for use in combination with anti-ASPA antibody made
Target Description: ASPA catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids.This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.
Product Categories/Family for ASPA blocking peptide
Peptide
Applications Tested/Suitable for ASPA blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ASPA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000040
[Other Products]
NCBI GenBank Nucleotide #
NM_000049
[Other Products]
UniProt Primary Accession #
P45381
[Other Products]
UniProt Related Accession #
P45381[Other Products]
NCBI Official Full Name
aspartoacylase
NCBI Official Synonym Full Names
aspartoacylase
NCBI Official Symbol
ASPA??[Similar Products]
NCBI Official Synonym Symbols
ASP; ACY2
??[Similar Products]
NCBI Protein Information
aspartoacylase
UniProt Protein Name
Aspartoacylase
UniProt Synonym Protein Names
Aminoacylase-2; ACY-2
Protein Family
Aspartocin
UniProt Gene Name
ASPA??[Similar Products]
UniProt Synonym Gene Names
ACY2; ASP; ACY-2??[Similar Products]
UniProt Entry Name
ACY2_HUMAN
NCBI Summary for ASPA
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ASPA
ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein type: Hydrolase; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - histidine; EC 3.5.1.15
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; hydrolase activity, acting on ester bonds; aspartoacylase activity; aminoacylase activity
Biological Process: myelination in the central nervous system; aspartate catabolic process; positive regulation of oligodendrocyte differentiation
Disease: Canavan Disease
Research Articles on ASPA
1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics
Precautions
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Disclaimer
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