Product Name
ASPA, Polyclonal Antibody
Popular Item
Full Product Name
ASPA Antibody
Product Synonym Names
ACY 2; ACY-2; ACY2; ACY2_HUMAN; Aminoacylase 2; Aminoacylase-2; Aminoacylase2; ASP; ASPA; Aspartoacylase (aminoacylase 2, Canavan disease); Aspartoacylase (Canavan disease); Aspartoacylase; NUR 7; NUR7; OTTMUSP00000006437; RP23-213I10.1; Small lethargic
Product Gene Name
anti-ASPA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P45381
Species Reactivity
Human, Mouse, Rat
Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog
Specificity
ASPA Antibody detects endogenous levels of ASPA.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human ASPA.
Tissue Specificity
Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
Subcellular Location
Nucleus
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-ASPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASPA antibody
Description: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
Subunit Structure: Homodimer.
Similarity: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Applications Tested/Suitable for anti-ASPA antibody
Western Blot (WB)
Application Notes for anti-ASPA antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-ASPA antibody
Western blot analysis of extracts from Mouse kidney tissue, using ASPA Antibody. The lane on the left was treated with blocking peptide.
NCBI/Uniprot data below describe general gene information for ASPA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000040.1
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NCBI GenBank Nucleotide #
NP_000040.1
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UniProt Primary Accession #
P45381
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UniProt Related Accession #
P45381[Other Products]
Molecular Weight
Observed: 36 kDa
Predicted: 36 kDa
NCBI Official Full Name
aspartoacylase
NCBI Official Synonym Full Names
aspartoacylase
NCBI Official Symbol
ASPA??[Similar Products]
NCBI Official Synonym Symbols
ASP; ACY2
??[Similar Products]
NCBI Protein Information
aspartoacylase
UniProt Protein Name
Aspartoacylase
UniProt Synonym Protein Names
Aminoacylase-2; ACY-2
Protein Family
Aspartocin
UniProt Gene Name
ASPA??[Similar Products]
UniProt Synonym Gene Names
ACY2; ASP; ACY-2??[Similar Products]
UniProt Entry Name
ACY2_HUMAN
NCBI Summary for ASPA
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ASPA
ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein type: Hydrolase; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - histidine; EC 3.5.1.15
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; hydrolase activity, acting on ester bonds; aspartoacylase activity; aminoacylase activity
Biological Process: myelination in the central nervous system; aspartate catabolic process; positive regulation of oligodendrocyte differentiation
Disease: Canavan Disease
Research Articles on ASPA
1. A;p.Ala305Glu, which is previously reported in ClinVar, in the gene ASPA was identified causing Canavan disease. In the second case, the homozygous novel variant NM_000487.5:c.256C>G;p.Arg86Gly in the gene ARSA was identified causing metachromatic leukodystrophy.">In one case, the homozygous pathogenic variant NM_000049.2:c.914C>A;p.Ala305Glu, which is previously reported in ClinVar, in the gene ASPA was identified causing Canavan disease. In the second case, the homozygous novel variant NM_000487.5:c.256C>G;p.Arg86Gly in the gene ARSA was identified causing metachromatic leukodystrophy.
Precautions
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