Product Name
Retinitis Pigmentosa 9 (RP9), Recombinant Protein
Full Product Name
Recombinant Human Retinitis Pigmentosa 9
Product Synonym Names
RP9 Human; Retinitis Pigmentosa 9 Human Recombinant; Retinitis pigmentosa 9 protein; Pim-1-associated protein; PAP-1; RP9
Product Gene Name
RP9 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MGSMSS RPGR EDVGAAGARR PREPPEQELQ RRREQKRRRH DAQQLQQLKH LESFYEKPPP GLIKEDETKP EDCIPDVPGN EHAREFLAHA PTKGLWMPLG KEVKVMQCWR CKRYGHRTGD KECPFFIKGN QKLEQFRVAH EDPMYDIIRD NKRHEKDV.< /u>
3D Structure
ModBase 3D Structure for Q8TA86
Purity/Purification
Greater than 85.0% as determined by SDS-PAGE.
Form/Format
RP9 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 20% glycerol and 1mM DTT.
Sterile Filtered colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of RP9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RP9 recombinant protein
Description: RP9 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 178 amino acids (1-155 a.a.) and having a molecular mass of 20.7kDa.RP9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: Retinitis pigmentosa 9 (RP9) is assumed to be a target protein for the PIM1 kinase. The RP9 protein may have some roles in B-cell proliferation in association with PIM1. RP9 can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase. RP9 localizes in nuclear speckles containing the splicing factors, and has a part in pre-mRNA splicing. RP9 gene mutations result in autosomal dominant retinitis pigmentosa-9.
Product Categories/Family for RP9 recombinant protein
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for RP9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_976033.1
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NCBI GenBank Nucleotide #
NM_203288.1
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UniProt Primary Accession #
Q8TA86
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UniProt Related Accession #
Q8TA86[Other Products]
Molecular Weight
26,107 Da
NCBI Official Full Name
retinitis pigmentosa 9 protein
NCBI Official Synonym Full Names
retinitis pigmentosa 9 (autosomal dominant)
NCBI Official Symbol
RP9??[Similar Products]
NCBI Official Synonym Symbols
PAP1; PAP-1
??[Similar Products]
NCBI Protein Information
retinitis pigmentosa 9 protein; Pim-1 kinase associated protein; pim-1-associated protein
UniProt Protein Name
Retinitis pigmentosa 9 protein
UniProt Synonym Protein Names
Pim-1-associated protein; PAP-1
Protein Family
Retinitis pigmentosa 9 protein
UniProt Gene Name
RP9??[Similar Products]
UniProt Synonym Gene Names
PAP-1??[Similar Products]
UniProt Entry Name
RP9_HUMAN
NCBI Summary for RP9
The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for RP9
RP9: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1. Defects in RP9 are the cause of retinitis pigmentosa type 9 (RP9). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP9 inheritance is autosomal dominant.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: nucleoplasm; signal recognition particle receptor complex; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding
Biological Process: RNA splicing; cognition
Disease: Retinitis Pigmentosa 9
Research Articles on RP9
1. Observational study of genetic testing. (HuGE Navigator)
Precautions
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Disclaimer
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