Full Product Name
MYD88 Polyclonal Antibody
Product Synonym Names
Mutant myeloid differentiation primary response 88; MYD 88; Myd88; MYD88; MYD88D; Myeloid differentiation marker 88; Myeloid differentiation primary response 88; Myeloid differentiation primary response gene (88); Myeloid differentiation primary response gene 88; Myeloid differentiation primary response gene; Myeloid differentiation primary response protein MyD88; OTTHUMP00000161718; OTTHUMP00000208595; OTTHUMP00000209058; OTTHUMP00000209059; OTTHUMP00000209060
Product Gene Name
anti-MYD88 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22366
Species Reactivity
Mouse, Rat
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
110 mug/mL (lot specific)
Immunogen
KLH conjugated synthetic peptide corresponding to Mouse MYD88
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-MYD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYD88 antibody
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Product Categories/Family for anti-MYD88 antibody
Cancer; Cardiovascular; Immunology; Signal Transduction
Applications Tested/Suitable for anti-MYD88 antibody
Immunohistochemistry (IHC)
Application Notes for anti-MYD88 antibody
IHC: 1:100-1:400
Immunohistochemistry (IHC) of anti-MYD88 antibody
Immunohistochemistry analysis of paraffin-embedded mouse lung using MYD88 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry (IHC) of anti-MYD88 antibody
Immunohistochemistry analysis of paraffin-embedded Rat kidney using MYD88 Polyclonal Antibody at dilution of 1:200.
NCBI/Uniprot data below describe general gene information for MYD88. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034981.1
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NCBI GenBank Nucleotide #
NM_010851.3
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UniProt Primary Accession #
P22366
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UniProt Secondary Accession #
O35916[Other Products]
UniProt Related Accession #
P22366[Other Products]
Molecular Weight
28,683 Da
NCBI Official Full Name
myeloid differentiation primary response protein MyD88
NCBI Official Synonym Full Names
myeloid differentiation primary response gene 88
NCBI Official Symbol
Myd88??[Similar Products]
NCBI Protein Information
myeloid differentiation primary response protein MyD88
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
Protein Family
Myeloid differentiation primary response protein
UniProt Gene Name
Myd88??[Similar Products]
UniProt Comments for MYD88
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:9697844). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9575168, PubMed:9697844). Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway (PubMed:9697844). Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS) (PubMed:11909531). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (PubMed:17018642). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (PubMed:17635956, PubMed:21998396). Mediates leukocyte recruitment at the inflammatory site (PubMed:18941239).
Research Articles on MYD88
1. cell-intrinsic and cell-extrinsic MyD88 signaling controls gene expression in conventional dendritic cells and orchestrates immune responses to inhaled allergens
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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