Product Name
Probable lysosomal cobalamin transporter (LMBRD1), Recombinant Protein
Full Product Name
Recombinant Human Probable lysosomal cobalamin transporter (LMBRD1), partial
Product Gene Name
LMBRD1 recombinant protein
[Similar Products]
Product Synonym Gene Name
LMBRD1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NUN5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of LMBRD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for LMBRD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_060838.3
[Other Products]
NCBI GenBank Nucleotide #
NM_018368.3
[Other Products]
UniProt Primary Accession #
Q9NUN5
[Other Products]
UniProt Secondary Accession #
Q5VUN6; Q86Y70; Q96FW4; Q9BY56; Q9NZD6; A8K204; E1P531[Other Products]
UniProt Related Accession #
Q9NUN5[Other Products]
Molecular Weight
21,394 Da
NCBI Official Full Name
probable lysosomal cobalamin transporter
NCBI Official Synonym Full Names
LMBR1 domain containing 1
NCBI Official Symbol
LMBRD1??[Similar Products]
NCBI Official Synonym Symbols
NESI; LMBD1; MAHCF; C6orf209
??[Similar Products]
NCBI Protein Information
probable lysosomal cobalamin transporter
UniProt Protein Name
Probable lysosomal cobalamin transporter
UniProt Synonym Protein Names
HDAg-L-interacting protein NESI; LMBR1 domain-containing protein 1; Nuclear export signal-interacting protein
UniProt Gene Name
LMBRD1??[Similar Products]
UniProt Synonym Gene Names
C6orf209; NESI??[Similar Products]
NCBI Summary for LMBRD1
This gene encodes a lysosomal membrane protein that may be involved in the transport and metabolism of cobalamin. This protein also interacts with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F.[provided by RefSeq, Oct 2009]
UniProt Comments for LMBRD1
Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
Research Articles on LMBRD1
1. Data suggest that ABCD4 lysosomal targeting depends on co-expression of and interaction with LMBRD1; mutations in LMBRD1 and ABCD4 that result in cobalamin metabolism disorders cblF and cblJ (or mutations in ATPase domain) disrupt interactions between LMBRD1 and ABCD4. (LMBRD1 = nuclear export signal-interacting protein; ABCD4 = ATP-binding cassette, sub-family D (ALD), member 4)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
