Insulin receptor-related protein; IRR; IR-related receptor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; Insrr; Irr

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Mouse Insrr antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1265-1295 amino acids from the C-terminal region of Mouse Insrr.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Insrr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Cardiovascular; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

Western blot analysis of lysate from rat brain tissue, using Mouse Insrr Antibody (C-term). MBS9204655 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.

144875

insulin receptor-related receptor

insulin receptor-related protein

Insulin receptor-related protein

Irr; IRR??[Similar Products]

INSRR_MOUSE

IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Protein type: EC 2.7.10.1; Membrane protein, integral; Protein kinase, TK; Kinase, protein; Protein kinase, tyrosine (receptor); TK group; InsR family

Cellular Component: membrane; integral to plasma membrane; integral to membrane; receptor complex

Molecular Function: transferase activity; protein-tyrosine kinase activity; insulin receptor substrate binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: peptidyl-tyrosine phosphorylation; male sex determination; protein amino acid autophosphorylation; actin cytoskeleton reorganization; signal transduction; phosphorylation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway

Hirayama I.,et al.Diabetes 48:1237-1244(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kitamura T.,et al.Mol. Cell. Biol. 21:5624-5630(2001).
Deyev I.E.,et al.Cell Metab. 13:679-689(2011).

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