Full Product Name
Insrr, CT (Insrr, Irr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain)
Product Synonym Names
Anti -Insrr, CT (Insrr, Irr, Insulin receptor-related protein, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain)
Product Gene Name
anti-INSRR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (156810665..156828712, complement). Location: 1q21-q23
3D Structure
ModBase 3D Structure for P14616
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
Mouse Insrr antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1227-1255 amino acids from the C-terminal region of Mouse Insrr.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-INSRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-INSRR antibody
This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
Product Categories/Family for anti-INSRR antibody
Antibodies; Abs to Insulin
Applications Tested/Suitable for anti-INSRR antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-INSRR antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for INSRR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055030.1
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NCBI GenBank Nucleotide #
NM_014215.2
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UniProt Primary Accession #
P14616
[Other Products]
UniProt Secondary Accession #
O60724; Q5VZS3[Other Products]
UniProt Related Accession #
P14616[Other Products]
Molecular Weight
143,720 Da[Similar Products]
NCBI Official Full Name
insulin receptor-related protein
NCBI Official Synonym Full Names
insulin receptor-related receptor
NCBI Official Symbol
INSRR??[Similar Products]
NCBI Official Synonym Symbols
IRR
??[Similar Products]
NCBI Protein Information
insulin receptor-related protein; IR-related receptor
UniProt Protein Name
Insulin receptor-related protein
UniProt Synonym Protein Names
IR-related receptor
Protein Family
Insulin receptor-related protein
UniProt Gene Name
INSRR??[Similar Products]
UniProt Synonym Gene Names
IRR; IRR??[Similar Products]
UniProt Entry Name
INSRR_HUMAN
UniProt Comments for INSRR
IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Protein type: Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; InsR family
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on INSRR
1. Analysis of structural determinants of alkali sensor IRR positive cooperativity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
