Full Product Name
INSRR Antibody
Product Synonym Names
IRR
Product Gene Name
anti-INSRR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Peptide of INSRR
Calculated Molecular Weight: 144kd
Observed Molecular Weight: 150-155kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19851 / sc-19850 / sc-19854 / sc-19855
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-INSRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-INSRR antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-INSRR antibody
WB: 1:500-1:5000
Testing Data of anti-INSRR antibody
NCBI/Uniprot data below describe general gene information for INSRR. It may not necessarily be applicable to this product.
NCBI Accession #
P14616.2
[Other Products]
UniProt Secondary Accession #
O60724; Q5VZS3[Other Products]
UniProt Related Accession #
P14616[Other Products]
Molecular Weight
143,720 Da
NCBI Official Full Name
Insulin receptor-related protein
NCBI Official Synonym Full Names
insulin receptor-related receptor
NCBI Official Symbol
INSRR??[Similar Products]
NCBI Official Synonym Symbols
IRR
??[Similar Products]
NCBI Protein Information
insulin receptor-related protein; IR-related receptor
UniProt Protein Name
Insulin receptor-related protein
UniProt Synonym Protein Names
IR-related receptorCleaved into the following 2 chains:Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain
Protein Family
Insulin receptor-related protein
UniProt Gene Name
INSRR??[Similar Products]
UniProt Synonym Gene Names
IRR; IRR??[Similar Products]
UniProt Entry Name
INSRR_HUMAN
UniProt Comments for INSRR
IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; InsR family
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; male sex determination; protein amino acid autophosphorylation; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on INSRR
1. IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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