Insulin receptor-related protein; IRR; IR-related receptor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; INSRR; IRR

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This INSRR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 668-702 amino acids from the Central region of human INSRR.

Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-INSRR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Crown Antibodies; Cardiovascular; Neuroscience

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

IHC~~1:25
WB~~1:1000

Immunohistochemical analysis of paraffin-embedded H. breast carcinoma section using INSRR Antibody (Center). MBS9208916 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

Immunohistochemical analysis of paraffin-embedded H. kidney section using INSRR Antibody (Center). MBS9208916 was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

Western blot analysis of lysates from A549, Hela, MCF-7, SH-SY5Y, SW480 cell line (from left to right), using INSRR Antibody (Center). MBS9208916 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

143720

insulin receptor-related receptor

insulin receptor-related protein

Insulin receptor-related protein

IRR; IRR??[Similar Products]

INSRR_HUMAN

IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Membrane protein, integral; Kinase, protein; TK group; InsR family

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: integral to plasma membrane; receptor complex

Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway

Haenze J.,et al.Horm. Metab. Res. 31:77-79(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Shier P.,et al.J. Biol. Chem. 264:14605-14608(1989).
Greenman C.,et al.Nature 446:153-158(2007).

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