Product Name
CYP4V2, Polyclonal Antibody
Full Product Name
CYP4V2 Polyclonal Antibody
Product Synonym Names
BCD; CP4V2; CYP4AH1; CYP4V 2; CYP4V2; Cytochrome P450 4V2; Cytochrome P450; family 4; subfamily V; polypeptide 2; Retina CYP4V2
Product Gene Name
anti-CYP4V2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6ZWL3
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration
1 mg/mL (lot specific)
Immunogen
Recombinant protein of human CYP4V2
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CYP4V2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYP4V2 antibody
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy.
Product Categories/Family for anti-CYP4V2 antibody
Cardiovascular; Metabolism
Applications Tested/Suitable for anti-CYP4V2 antibody
Western Blot (WB)
Application Notes for anti-CYP4V2 antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-CYP4V2 antibody
Western blot analysis of extracts of various cell lines, using CYP4V2 Antibody.
NCBI/Uniprot data below describe general gene information for CYP4V2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_997235.3
[Other Products]
NCBI GenBank Nucleotide #
NM_207352.4
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UniProt Primary Accession #
Q6ZWL3
[Other Products]
UniProt Secondary Accession #
Q6ZTM4; B7U6W2[Other Products]
UniProt Related Accession #
Q6ZWL3[Other Products]
Molecular Weight
Calculated: 58kDa; 60kDa
Observed: 54kDa
NCBI Official Full Name
cytochrome P450 4V2
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily V member 2
NCBI Official Symbol
CYP4V2??[Similar Products]
NCBI Official Synonym Symbols
BCD; CYP4AH1
??[Similar Products]
NCBI Protein Information
cytochrome P450 4V2
UniProt Protein Name
Cytochrome P450 4V2
UniProt Synonym Protein Names
Docosahexaenoic acid omega-hydroxylase CYP4V2Curated (EC:1.14.14.791 PublicationManual assertion based on experiment iniRef.7"CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of omega-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant."Nakano M., Kelly E.J., Wiek C., Hanenberg H., Rettie A.E.Mol. Pharmacol. 82:679-686(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, CHARACTERIZATION OF VARIANT BCD PRO-331.
Protein Family
Cytochrome
UniProt Gene Name
CYP4V2??[Similar Products]
NCBI Summary for CYP4V2
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP4V2
Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).
Research Articles on CYP4V2
1. To the best of our knowledge, this study represents the largest effort to determine the genetic alterations underlying Bietti crystalline dystrophy (BCD) in Spain to date. Our results show that analysis of CYP4V2 variants is required for a reliable diagnosis of BCD.
Precautions
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