Product Name
CYP4V2, Polyclonal Antibody
Full Product Name
CYP4V2 Antibody (Rabbit Polyclonal)
Product Gene Name
anti-CYP4V2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human
Predicted: Mouse, Rat
Form/Format
Purified by protein affinity column containing 1% BSA and 0.02% NaN3
Preparation and Storage
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
Other Notes
Small volumes of anti-CYP4V2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYP4V2 antibody
Rabbit polyclonal CYP4V2 (1) antibody was raised against a recombinate human CYP4V2 protein 309-486aa (BC060857).
Applications Tested/Suitable for anti-CYP4V2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CYP4V2 antibody
ELISA: 1:20,000-1:80,000
WB: 1:200-1:1,000
NCBI/Uniprot data below describe general gene information for CYP4V2. It may not necessarily be applicable to this product.
NCBI Accession #
BC060857
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UniProt Secondary Accession #
Q6ZTM4; B7U6W2[Other Products]
UniProt Related Accession #
Q6ZWL3[Other Products]
Molecular Weight
58,166 Da
NCBI Official Full Name
Homo sapiens cytochrome P450, family 4, subfamily V, polypeptide 2, mRNA
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily V member 2
NCBI Official Symbol
CYP4V2??[Similar Products]
NCBI Official Synonym Symbols
BCD; CYP4AH1
??[Similar Products]
NCBI Protein Information
cytochrome P450 4V2
UniProt Protein Name
Cytochrome P450 4V2
UniProt Synonym Protein Names
Docosahexaenoic acid omega-hydroxylase CYP4V2
Protein Family
Cytochrome
UniProt Gene Name
CYP4V2??[Similar Products]
NCBI Summary for CYP4V2
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP4V2
Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592).
Research Articles on CYP4V2
1. This is the first report of a homozygous R400C mutation in CYP4V2 with protein modelling showing high likelihood of enzyme dysfunction. The comprehensive long-term clinical follow-up provides insight into disease progression and highlights possible anti-inflammatory modulation of disease severity.
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