Product Name
CYP4V2, cDNA Clone
Full Product Name
CYP4V2 cDNA Clone
Product Gene Name
CYP4V2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggggc tctggctggg gctcgtgtgg cagaagctgc tgctgtgggg cgcggcgagt gccctttccc tggccggcgc cagtctggtc ctgagcctgc tgcagagggt ggcgagctac gcgcggaaat ggcagcagat gcggcccatc cccacggtgg cccgcgccta cccactggtg ggccacgcgc tgctgatgaa gccggacggg cgagaatttt ttcagcagat cattgagtac acagaggaat accgccacat gccgctgctg aagctctggg tcgggccagt gcccatggtg gccctttata atgcagaaaa tgtggaggta attttaacta gttcaaagca aattgacaaa tcctctatgt acaagttttt agaaccatgg cttggcctag gacttcttac aagtactgga aacaaatggc gctccaggag aaagatgtta acacccactt tccattttac cattctggaa gatttcttag atatcatgaa tgaacaagca aatatattgg ttaagaaact tgaaaaacac attaaccaag aagcatttaa ctgctttttt tacatcactc tttgtgcctt agatatcatc tgtgaaacag ctatggggaa gaatattggt gctcaaagta atgatgattc cgagtatgtc cgtgcagttt atagaatgag tgagatgata tttcgaagaa taaagatgcc ctggctttgg cttgatctct ggtaccttat gtttaaagaa ggatgggaac acaaaaagag ccttaagatc ctacatactt ttaccaacag tgtcatcgcg gaacgggcca atgaaatgaa cgccaatgaa gactgtagag gtgatggcag gggctctgcc ccctccaaaa ataaacgcag ggcctttctt gacttgcttt taagtgtgac tgatgacgaa gggaacaggc taagtcatga agatattcga gaagaagttg acaccttcat gtttgagggg cacgatacaa ctgcagctgc aataaactgg tccttatacc tgttgggttc taacccagaa gtccagaaaa aagtggatca tgaattggat gacgtgtttg ggaagtctga ccgtcccgct acagtagaag acctgaagaa acttcggtat ctggaatgtg ttattaagga gacccttcgc ctttttcctt ctgttccttt atttgcccgt agtgttagtg aagattgtga agtggcaggt tacagagttc taaaaggcac tgaagccgtc atcattccct atgcattgca cagagatccg agatacttcc ccaaccccga ggagttccag cctgagcggt tcttccccga gaatgcacaa gggcgccatc catatgccta cgtgcccttc tctgctggcc ccaggaactg tataggtcaa aagtttgctg tgatggaaga aaagaccatt ctttcgtgca tcctgaggca cttttggata gaatccaacc agaaaagaga agagcttggt ctagaaggac agttgattct tcgtccaagt aatggcatct ggatcaagtt gaagaggaga aatgcagatg aacgctaa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CYP4V2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CYP4V2. It may not necessarily be applicable to this product.
NCBI Accession #
BC060857
[Other Products]
UniProt Secondary Accession #
Q6ZTM4; B7U6W2[Other Products]
UniProt Related Accession #
Q6ZWL3[Other Products]
Molecular Weight
58,166 Da
NCBI Official Full Name
Homo sapiens cytochrome P450, family 4, subfamily V, polypeptide 2, mRNA
NCBI Official Synonym Full Names
cytochrome P450 family 4 subfamily V member 2
NCBI Official Symbol
CYP4V2??[Similar Products]
NCBI Official Synonym Symbols
BCD; CYP4AH1
??[Similar Products]
NCBI Protein Information
cytochrome P450 4V2
UniProt Protein Name
Cytochrome P450 4V2
UniProt Synonym Protein Names
Docosahexaenoic acid omega-hydroxylase CYP4V2
Protein Family
Cytochrome
UniProt Gene Name
CYP4V2??[Similar Products]
UniProt Entry Name
CP4V2_HUMAN
NCBI Summary for CYP4V2
This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 polyunsaturated fatty acids. Mutations in this gene result in Bietti crystalline corneoretinal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP4V2
CYP4V2: Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye. Defects in CYP4V2 are a cause of Bietti crystalline corneoretinal dystrophy (BCD). BCD is an autosomal recessive retinal dystrophy characterized by multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most cases have similar crystals at the corneoscleral limbus. Clinically, BCD is progressive. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, patients develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.14.13.199; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q35.2
Cellular Component: endoplasmic reticulum membrane
Molecular Function: monooxygenase activity
Biological Process: fatty acid omega-oxidation; retinoid metabolic process; sterol metabolic process
Disease: Bietti Crystalline Corneoretinal Dystrophy
Research Articles on CYP4V2
1. In Bietti crystalline dystrophy patients with CYP4V2 mutations, cone density remained for visual dysfunction by evaluation using high-resolution AO-SLO.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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