Product Name
PTPN4, Polyclonal Antibody
Popular Item
Full Product Name
PTPN4 Polyclonal Antibody
Product Synonym Names
MEG; PTPMEG; PTPMEG1
Product Gene Name
anti-PTPN4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29074
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human PTPN4
Calculated Molecular Weight
106kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-PTPN4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTPN4 antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Product Categories/Family for anti-PTPN4 antibody
Polyclonal
Applications Tested/Suitable for anti-PTPN4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PTPN4 antibody
WB: 1:200-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-PTPN4 antibody
Western blot analysis of extracts of various cell lines, using PTPN4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 15s.
NCBI/Uniprot data below describe general gene information for PTPN4. It may not necessarily be applicable to this product.
NCBI Accession #
P29074.1
[Other Products]
UniProt Primary Accession #
P29074
[Other Products]
UniProt Secondary Accession #
Q9UDA7; B2RBV8[Other Products]
UniProt Related Accession #
P29074[Other Products]
NCBI Official Full Name
Tyrosine-protein phosphatase non-receptor type 4
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
NCBI Official Symbol
PTPN4??[Similar Products]
NCBI Official Synonym Symbols
MEG; PTPMEG; PTPMEG1
??[Similar Products]
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 4
UniProt Synonym Protein Names
Protein-tyrosine phosphatase MEG1; MEG; PTPase-MEG1
Protein Family
Tyrosine-protein phosphatase non-receptor
UniProt Gene Name
PTPN4??[Similar Products]
UniProt Synonym Gene Names
MEG; PTPase-MEG1??[Similar Products]
UniProt Entry Name
PTN4_HUMAN
NCBI Summary for PTPN4
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
UniProt Comments for PTPN4
PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 2q14.2
Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm
Molecular Function: protein binding; cytoskeletal protein binding; non-membrane spanning protein tyrosine phosphatase activity
Biological Process: protein amino acid dephosphorylation
Research Articles on PTPN4
1. The physiologically active PTPN4 two-domain (the PDZ and the phosphatase domains) adopts a predominant compact conformation in solution. PDZ ligand binding restores the catalytic competence of PTPN4 disrupting the transient interdomain communication.
Precautions
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