Product Name
c-Myb, Blocking Peptide
Full Product Name
c-Myb Blocking Peptide
Product Synonym Names
Transcriptional activator Myb; Proto-oncogene c-Myb
Product Gene Name
MYB blocking peptide
[Similar Products]
c-Myb peptide (MBS8201085) is used for blocking the activity of c-Myb antibody (MBS8240689)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10242
Species Reactivity
Human, Mouse, Rat, Bovine
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of MYB blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MYB blocking peptide
The peptide is used to block Anti-c-Myb Antibody reactivity.
Applications Tested/Suitable for MYB blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for MYB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123644.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130172.1
[Other Products]
UniProt Primary Accession #
P10242
[Other Products]
UniProt Secondary Accession #
P78391; P78392; P78525; P78526; Q14023; Q14024; E9PI07; E9PLZ5; E9PNA4; E9PNL6; E9PRS2[Other Products]
UniProt Related Accession #
P10242[Other Products]
Molecular Weight
37,507 Da
NCBI Official Full Name
transcriptional activator Myb isoform 3
NCBI Official Synonym Full Names
v-myb avian myeloblastosis viral oncogene homolog
NCBI Official Symbol
MYB??[Similar Products]
NCBI Official Synonym Symbols
efg; Cmyb; c-myb; c-myb_CDS
??[Similar Products]
NCBI Protein Information
transcriptional activator Myb
UniProt Protein Name
Transcriptional activator Myb
UniProt Synonym Protein Names
Proto-oncogene c-Myb
Protein Family
Myb protein
UniProt Gene Name
MYB??[Similar Products]
UniProt Entry Name
MYB_HUMAN
NCBI Summary for MYB
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
UniProt Comments for MYB
Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 6q22-q23
Cellular Component: nuclear matrix; cytosol
Molecular Function: protein binding; chromatin binding
Biological Process: positive regulation of histone H3-K9 methylation; transcription, DNA-dependent; thymus development; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; B cell differentiation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; embryonic gut development; G1/S transition of mitotic cell cycle
Research Articles on MYB
1. Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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