Full Product Name
Anti-c-Myb (AcK471) Antibody
Product Synonym Names
Transcriptional activator Myb; Proto-oncogene c-Myb
Product Gene Name
anti-MYB antibody
[Similar Products]
Antibody/Peptide Pairs
c-Myb peptide (MBS8247819) is used for blocking the activity of c-Myb antibody (MBS8248107)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10242
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of c-Myb (AcK471) protein.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human c-Myb. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-MYB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYB antibody
Rabbit polyclonal antibody to c-Myb (AcK471)
Applications Tested/Suitable for anti-MYB antibody
Western Blot (WB)
Application Notes for anti-MYB antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-MYB antibody
Western blot analysis of c-Myb (AcK471) expression in BV2 (A), C6 (B), rat brain (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for MYB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123644.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130172.1
[Other Products]
UniProt Primary Accession #
P10242
[Other Products]
UniProt Secondary Accession #
P78391; P78392; P78525; P78526; Q14023; Q14024; E9PI07; E9PLZ5; E9PNA4; E9PNL6; E9PRS2[Other Products]
UniProt Related Accession #
P10242[Other Products]
Molecular Weight
37,507 Da
NCBI Official Full Name
transcriptional activator Myb isoform 3
NCBI Official Synonym Full Names
MYB proto-oncogene, transcription factor
NCBI Official Symbol
MYB??[Similar Products]
NCBI Official Synonym Symbols
efg; Cmyb; c-myb; c-myb_CDS
??[Similar Products]
NCBI Protein Information
transcriptional activator Myb
UniProt Protein Name
Transcriptional activator Myb
UniProt Synonym Protein Names
Proto-oncogene c-Myb
Protein Family
Myb protein
UniProt Gene Name
MYB??[Similar Products]
UniProt Entry Name
MYB_HUMAN
NCBI Summary for MYB
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for MYB
Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 6q22-q23
Cellular Component: nucleus
Molecular Function: protein binding
Biological Process: chromatin remodeling; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent
Research Articles on MYB
1. The MYB/MAF co-silencing constrained the skewing of erythroid versus megakaryocyte lineage commitment in MYB-silenced CD34+ cells, by restraining the expansion of megakaryocyte lineage while partially rescuing the impairment of erythropoiesis.
Precautions
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Disclaimer
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