Full Product Name
c-Myb Polyclonal Antibody
Product Synonym Names
MYB; Transcriptional activator Myb; Proto-oncogene c-Myb
Product Gene Name
anti-c-Myb antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10242
Species Reactivity
Human, Mouse
Specificity
c-Myb Polyclonal Antibody detects endogenous levels of c-Myb protein only when non-acetylation at K480.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from human c-Myb around the non-acetylation site of K480.
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-c-Myb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-c-Myb antibody
Total protein Ab
Applications Tested/Suitable for anti-c-Myb antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-c-Myb antibody
Western Blot: 1:500 - 1:2000
ELISA: 1:20000
Not yet tested in other applications.
Western Blot (WB) of anti-c-Myb antibody
Western Blot analysis of MCF7 cells using c-Myb Polyclonal Antibody.
NCBI/Uniprot data below describe general gene information for c-Myb. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001123644.1
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NCBI GenBank Nucleotide #
NM_001130172.1
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UniProt Primary Accession #
P10242
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UniProt Secondary Accession #
P78391; P78392; P78525; P78526; Q14023; Q14024; E9PI07; E9PLZ5; E9PNA4; E9PNL6; E9PRS2[Other Products]
UniProt Related Accession #
P10242[Other Products]
Molecular Weight
37,507 Da
NCBI Official Full Name
transcriptional activator Myb isoform 3
NCBI Official Synonym Full Names
v-myb avian myeloblastosis viral oncogene homolog
NCBI Official Symbol
MYB??[Similar Products]
NCBI Official Synonym Symbols
efg; Cmyb; c-myb; c-myb_CDS
??[Similar Products]
NCBI Protein Information
transcriptional activator Myb
UniProt Protein Name
Transcriptional activator Myb
UniProt Synonym Protein Names
Proto-oncogene c-Myb
UniProt Gene Name
MYB??[Similar Products]
UniProt Entry Name
MYB_HUMAN
NCBI Summary for c-Myb
This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
UniProt Comments for c-Myb
Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6q22-q23
Cellular Component: nuclear matrix; cytosol
Molecular Function: protein binding; chromatin binding
Biological Process: positive regulation of histone H3-K9 methylation; transcription, DNA-dependent; thymus development; in utero embryonic development; positive regulation of transcription, DNA-dependent; homeostasis of number of cells; positive regulation of histone H3-K4 methylation; negative regulation of transcription from RNA polymerase II promoter; chromatin remodeling; positive regulation of T-helper cell differentiation; regulation of transcription, DNA-dependent; B cell differentiation; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; negative regulation of transcription, DNA-dependent; embryonic gut development; G1/S transition of mitotic cell cycle
Research Articles on c-Myb
1. Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.
Precautions
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Disclaimer
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