FOX-P1; 12CC4; QRF1; HFKH1B; Fork Head-Related Protein Like B; Glutamine-Rich Factor 1; PAX5/FOXP1 Fusion Protein

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against FOXP1. It has been selected for its ability to recognize FOXP1 in immunohistochemical staining and western blotting.

Affinity Chromatography

Supplied as solution form in PBS, pH7.4 containing 0.02% NaN3, 50% glycerol.

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-FOXP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western Blot: 1:50-400
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot: Sample: Mouse Heart lysate; Primary Ab: 3ug/ml Rabbit Anti-Mouse FOXP1 Antibody Second Ab: 0.2ug/mL?HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody

Western Blot: Sample: Recombinant protein.

DAB staining on fromalin fixed paraffin- embedded Kidney tissue)

80,762 Da

forkhead box P1

forkhead box protein P1

Forkhead box protein P1

FOXP1: Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development. Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6|6 D3

Cellular Component: cytoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; DNA binding transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding

Biological Process: cardiac muscle cell differentiation; embryonic development; heart development; immunoglobulin V(D)J recombination; in utero embryonic development; lung development; motor axon guidance; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; positive regulation of immunoglobulin production; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; pre-B cell differentiation; regulation of cardiac muscle cell proliferation; regulation of transcription, DNA-templated; sarcomere organization; skeletal muscle tissue development; smooth muscle development; transcription, DNA-dependent; ventral spinal cord development

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